Yonsei Med J. 1993 Dec;34(4):321-327. English.
Published online Feb 20, 2002.
https://doi.org/10.3349/ymj.1993.34.4.321
Published online Feb 20, 2002.
https://doi.org/10.3349/ymj.1993.34.4.321
Copyright © 1993 The Yonsei University College of Medicine
Original Article
Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP
Mineki Saito,
Takashi Moritoyo,
Jae Hyeon Park,
Byung In Lee,
Jin Soo Kim,
Jun ichi Fujisawa,
Mitsuhiro Osame
and Mitsuaki Yoshida
Abstract
Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins
Keywords
HTLV-I; HAM/TSP; polymerase chain reaction; nucleotide sequence analysis
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