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Year 2022, Volume: 5 Issue: 4, 1114 - 1118, 20.07.2022
https://doi.org/10.32322/jhsm.1109130

Abstract

References

  • Li S, Wang J, Zhang B, Li X, Liu Y. Diabetes mellitus and cause-specific mortality: a population-based study. Diabetes Metab J 2019; 43: 319-41.
  • Walpole SC, Prieto-Merino D, Edwards P, et al. The weight of nations: an estimation of adult human biomass. BMC Public Health 2012; 12: 439.
  • Attar SM. Musculoskeletal manifestations in diabetic patients at a tertiary center. Libyan J Med 2012; 7: 19162.
  • Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14: 88-98.
  • Mathew AJ, Nair JB, Pillai SS. Rheumatic-musculoskeletal manifestations in type 2 diabetes mellitus patients in south India. Int J Rheum Dis 2011; 14: 55-60.
  • Hoff OM, Midthjell K, Zwart JA, Hag. The association between diabetes mellitus, glucose, and chronic musculoskeletal complaints. Results from the Nord-Trøndelag Health Study. BMC Musculoskelet Disord 2008; 9: 160.
  • Ramchurn N, Mashamba C, Leitch E, et al. Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes. Eur J Intern Med 2009; 20: 718-21.
  • Chanchek N, Gersing AS, Schwaiger BJ, et al. Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative. J Magn Reson Imaging 2018; 47: 380-90.
  • King KB, Rosenthal AK. The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. Osteoarthr Cartil 2015; 23: 841–50.
  • Jingsheng S, Yibing W, Jun X, et al. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis. J Bone Miner Metab 2015; 33: 1-8.
  • Kirkman MS. Osteoarthritis progression: is diabetes a culprit? Osteoarthritis Cartilage 2015; 23: 839–40.
  • Kovács B, Vajda E, Nagy EE. Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis. Int J Mol Sci 2019; 20: 4653
  • Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986; 29: 1039-49
  • Holden MK, Kathlee MG, Magliozzi MR, et al. Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness. Phys Ther 1986; 66: 1530-9.
  • Tüzün EH, Eker L, Aytar A, Daşkapan A, Bayramoğlu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthr Cartil 2005; 13: 28-33.
  • Faucher M, Poiraudeau S, Lefevre-Colau MM, Rannou F, Fermanian J, Revel M. Assessment of the test-retest reliability and construct validity of a modified Lequesne index in knee osteoarthritis. Joint Bone Spine 2003; 70: 521-5.
  • Paker N, Buğdaycı D, Sabırlı F, Özel S, Ersoy S. Knee Injury and Osteoarthritis Outcome Score: Reliability and Validation of the Turkish Version. J Med Sci 2007; 27: 350-6.
  • Koçyiğit H, Aydemir Ö, Fişek G, Ölmez N, Memiş A. Kısa Form–36 (KF-36)’nın Türkçe versiyonunun güvenilirliği ve geçerliliği. Romatizmal hastalığı olan bir grup hasta ile çalışma. İlaç ve Tedavi Derg 1999; 12: 102-6.
  • Petersson IF, Boegård T, Saxne T, Silman AJ, Svensson B. Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain. Ann Rheum Dis 1997; 56: 493-6.
  • Xie C, Chen Q. Adipokines: New Therapeutic Target for Osteoarthritis? Curr Rheumatol Rep 2019; 21: 71.
  • Eymard F, Parsons C, Edwards MH, et al. Diabetes is a risk factor for knee osteoarthritis progression. Osteoarthritis Cartilage 2015; 23: 851-9.
  • Al-Jarallah K, Shehab D, Abdella N, Mohamedy H, Abraham M. Knee osteoarthritis in type 2 diabetes mellitus: does insulin therapy retard osteophyte formation? Med Princ Pract 2016; 25: 12–7.
  • Horn CA, Bradley JD, Brandt KD, Kreipke DL, Slowman SD, Kalasinski LA. Impairment of osteophyte formation in hyperglycemic patients with type II diabetes mellitus and knee osteoarthritis. Arthritis Rheum 1992; 35: 336-42.
  • Cai L, Okumu FW, Cleland JL, et al. A slow release formulation of insulin as a treatment for osteoarthritis. Osteoarthr Cartil 2002; 10: 692-706.
  • Takagi S, Omori G, Koga H, et al. Quadriceps muscle weakness is related to increased risk of radiographic knee OA but not its progression in both women and men: the Matsudai Knee Osteoarthritis Survey. Knee Surg Sports Traumatol Arthrosc 2018; 26: 2607-14.
  • Wada O, Kurita N, Yamada M, Mizuno K. Structural severity, phase angle, and quadriceps strength among patients with knee osteoarthritis: the SPSS-OK study. Clin Rheumatol 2020; 39: 3049-56.
  • Palmieri-Smith RM, Thomas AC, Karvonen-Gutierrez C, Sowers MF. Isometric quadriceps strength in women with mild, moderate, and severe knee osteoarthritis. Am J Phys Med Rehabil 2010; 89: 541–8.
  • Eitner A, Pester J, Vogel F, et al. Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus. Pain 2017; 158: 1743-53.
  • Baldwin JN, McKay MJ, Simic M, et al. Self-reported knee pain and disability among healthy individuals: reference data and factors associated with the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child. Osteoarthr Cartil 2017; 25: 1282-90.
  • Elena VZ, Alexander PL, Elena PT, Olga VS. Characterization of osteoarthritis in patients with diabetes mellitus type 2. Integr Mol Med 2016; 3: 649-53.
  • Antje M, Katja H, Andreas R, et al. Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey. Health Qual Life Outcomes 2009; 27: 19.
  • Vitaloni M, Botto-van Bemden A, Sciortino Contreras RM, et al. Global management of patients with knee osteoarthritis begins with quality of life assessment: a systematic review. BMC Musculoskelet Disord 2019; 20: 493.
  • Eriksson KF, Lindgärde F. Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men. Diabetologia 1996; 39: 573-9.
  • Andersen H, Poulsen PL, Mogensen CE, Jakobsen J. Isokinetic muscle strength in long-term IDDM patients in relation to diabetic complications. Diabetes 1996; 45: 440-5.

The association between diabetes mellitus and functionality in knee osteoarthritis: a cross-sectional study

Year 2022, Volume: 5 Issue: 4, 1114 - 1118, 20.07.2022
https://doi.org/10.32322/jhsm.1109130

Abstract

Objective: The aim of this study was to determine the roles of diabetes mellitus (DM) on quality of life, function of knee, and muscle strength in patients with knee osteoarthritis (OA).
Material and Method: This single-center, case-control study prospectively enrolled outpatients with knee OA visiting a physical therapy and rehabilitation clinic. The patients were grouped according to the presence of DM diagnosis. Demographic data, disease duration, and medical treatments of patients were recorded. Clinical parameters, radiographic grading (Kellgren-Lawrence grades), functional scales of the knee and quality of life were evaluated.
Results: The study included 82 participants [age: 61.3±6.7 years; female: 76.8%]. The mean Western Ontario and McMaster Universities Osteoarthritis Index of OA patients with (n=37) and without DM (n=45) were 45.79±18.04 vs. 65.94±16.23, respectively (p=0.003). The Hb A1c levels showed a negative correlation with Knee Injury and Osteoarthritis Outcome Score components (pain, quality of life, sports, daily activities, symptom duration) (p<0.001, r:-0.440; p<0.001, r:-0.393; p<0.001, r:-0.396; p<0.001, r:-0.336; p:0.002, r:-0.342, respectively) and also, a negative correlation with knee flexion degree (p<0.001, r:-0.401).
Conclusion: DM has a negative effect on quality of life and activities of life in knee OA.

References

  • Li S, Wang J, Zhang B, Li X, Liu Y. Diabetes mellitus and cause-specific mortality: a population-based study. Diabetes Metab J 2019; 43: 319-41.
  • Walpole SC, Prieto-Merino D, Edwards P, et al. The weight of nations: an estimation of adult human biomass. BMC Public Health 2012; 12: 439.
  • Attar SM. Musculoskeletal manifestations in diabetic patients at a tertiary center. Libyan J Med 2012; 7: 19162.
  • Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14: 88-98.
  • Mathew AJ, Nair JB, Pillai SS. Rheumatic-musculoskeletal manifestations in type 2 diabetes mellitus patients in south India. Int J Rheum Dis 2011; 14: 55-60.
  • Hoff OM, Midthjell K, Zwart JA, Hag. The association between diabetes mellitus, glucose, and chronic musculoskeletal complaints. Results from the Nord-Trøndelag Health Study. BMC Musculoskelet Disord 2008; 9: 160.
  • Ramchurn N, Mashamba C, Leitch E, et al. Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes. Eur J Intern Med 2009; 20: 718-21.
  • Chanchek N, Gersing AS, Schwaiger BJ, et al. Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative. J Magn Reson Imaging 2018; 47: 380-90.
  • King KB, Rosenthal AK. The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. Osteoarthr Cartil 2015; 23: 841–50.
  • Jingsheng S, Yibing W, Jun X, et al. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis. J Bone Miner Metab 2015; 33: 1-8.
  • Kirkman MS. Osteoarthritis progression: is diabetes a culprit? Osteoarthritis Cartilage 2015; 23: 839–40.
  • Kovács B, Vajda E, Nagy EE. Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis. Int J Mol Sci 2019; 20: 4653
  • Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986; 29: 1039-49
  • Holden MK, Kathlee MG, Magliozzi MR, et al. Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness. Phys Ther 1986; 66: 1530-9.
  • Tüzün EH, Eker L, Aytar A, Daşkapan A, Bayramoğlu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthr Cartil 2005; 13: 28-33.
  • Faucher M, Poiraudeau S, Lefevre-Colau MM, Rannou F, Fermanian J, Revel M. Assessment of the test-retest reliability and construct validity of a modified Lequesne index in knee osteoarthritis. Joint Bone Spine 2003; 70: 521-5.
  • Paker N, Buğdaycı D, Sabırlı F, Özel S, Ersoy S. Knee Injury and Osteoarthritis Outcome Score: Reliability and Validation of the Turkish Version. J Med Sci 2007; 27: 350-6.
  • Koçyiğit H, Aydemir Ö, Fişek G, Ölmez N, Memiş A. Kısa Form–36 (KF-36)’nın Türkçe versiyonunun güvenilirliği ve geçerliliği. Romatizmal hastalığı olan bir grup hasta ile çalışma. İlaç ve Tedavi Derg 1999; 12: 102-6.
  • Petersson IF, Boegård T, Saxne T, Silman AJ, Svensson B. Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain. Ann Rheum Dis 1997; 56: 493-6.
  • Xie C, Chen Q. Adipokines: New Therapeutic Target for Osteoarthritis? Curr Rheumatol Rep 2019; 21: 71.
  • Eymard F, Parsons C, Edwards MH, et al. Diabetes is a risk factor for knee osteoarthritis progression. Osteoarthritis Cartilage 2015; 23: 851-9.
  • Al-Jarallah K, Shehab D, Abdella N, Mohamedy H, Abraham M. Knee osteoarthritis in type 2 diabetes mellitus: does insulin therapy retard osteophyte formation? Med Princ Pract 2016; 25: 12–7.
  • Horn CA, Bradley JD, Brandt KD, Kreipke DL, Slowman SD, Kalasinski LA. Impairment of osteophyte formation in hyperglycemic patients with type II diabetes mellitus and knee osteoarthritis. Arthritis Rheum 1992; 35: 336-42.
  • Cai L, Okumu FW, Cleland JL, et al. A slow release formulation of insulin as a treatment for osteoarthritis. Osteoarthr Cartil 2002; 10: 692-706.
  • Takagi S, Omori G, Koga H, et al. Quadriceps muscle weakness is related to increased risk of radiographic knee OA but not its progression in both women and men: the Matsudai Knee Osteoarthritis Survey. Knee Surg Sports Traumatol Arthrosc 2018; 26: 2607-14.
  • Wada O, Kurita N, Yamada M, Mizuno K. Structural severity, phase angle, and quadriceps strength among patients with knee osteoarthritis: the SPSS-OK study. Clin Rheumatol 2020; 39: 3049-56.
  • Palmieri-Smith RM, Thomas AC, Karvonen-Gutierrez C, Sowers MF. Isometric quadriceps strength in women with mild, moderate, and severe knee osteoarthritis. Am J Phys Med Rehabil 2010; 89: 541–8.
  • Eitner A, Pester J, Vogel F, et al. Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus. Pain 2017; 158: 1743-53.
  • Baldwin JN, McKay MJ, Simic M, et al. Self-reported knee pain and disability among healthy individuals: reference data and factors associated with the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child. Osteoarthr Cartil 2017; 25: 1282-90.
  • Elena VZ, Alexander PL, Elena PT, Olga VS. Characterization of osteoarthritis in patients with diabetes mellitus type 2. Integr Mol Med 2016; 3: 649-53.
  • Antje M, Katja H, Andreas R, et al. Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey. Health Qual Life Outcomes 2009; 27: 19.
  • Vitaloni M, Botto-van Bemden A, Sciortino Contreras RM, et al. Global management of patients with knee osteoarthritis begins with quality of life assessment: a systematic review. BMC Musculoskelet Disord 2019; 20: 493.
  • Eriksson KF, Lindgärde F. Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men. Diabetologia 1996; 39: 573-9.
  • Andersen H, Poulsen PL, Mogensen CE, Jakobsen J. Isokinetic muscle strength in long-term IDDM patients in relation to diabetic complications. Diabetes 1996; 45: 440-5.
There are 34 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Serdar Kaymaz 0000-0002-6958-5436

Sanem Aslıhan Aykan 0000-0001-7335-5556

Publication Date July 20, 2022
Published in Issue Year 2022 Volume: 5 Issue: 4

Cite

AMA Kaymaz S, Aykan SA. The association between diabetes mellitus and functionality in knee osteoarthritis: a cross-sectional study. J Health Sci Med / JHSM. July 2022;5(4):1114-1118. doi:10.32322/jhsm.1109130

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