Rasulullah Shallahu’alaihiwassalam said, “if a fly falls in the vessel anyone of you, let him dip all of it (in the vessel) and then throw it away, for in one of its wings has the ailment and the other has the cure” (Al-Bukhari). This hadith creates controversy because in general flies are a vector for the spread of disease from dirty places to food or drinks. Therefore, the research was conducted on right-wing of fly (Musca domestica) as neutralization of drinks contaminated by a microbe. This research used the method of Complete Random Design by 5 treatments and 2 repetitions. The treatment was done by sterilized water (positive control), drinking water added to the bacteria Escherichia coli (negative control), and drinking water contaminated by Escherichia coli bacteria with the addition of 1, 2, and 3 flies right-wings. The research began with taking the right-wing of fly and continued with the dilution of Escherichia coli culture tubes up to 6 times. The bacterial culture inoculation was carried out using Pour Plate method on Eosin Methylene Blue agar which is incubated for 12–48 h at a temperature of 37ºC. Data retrieval is done by observing the calculation of the number of microbes using a colony counter every 12 h. The data which obtained for 48 h incubation show “0” as the result, that cannot be analyzed with SPSS. The result indicates the microbial development does not occur on contaminated drinks by addition with right-wing of Musca domestica.