An account of the Anthicidae (ant-like flower beetles) and associated incertae sedis groups of Chile is presented. Forty seven species and subspecies are confirmed for the country (Anthicinae, Copobaeninae, Eurygeniinae, Lagrioidinae, Lemodinae, Tomoderinae), including 11 new to science: Ischyropalpus aberratus, I. quadrimaculatus, I. similis, Sapintus costae, Tomoderus cavithorax, T. differens, T. melanocephalus, T. nahuelbuta, Trichananca inexpectata, T. neotropica, T. poggiispp. nov.ProtoanthicusMoore et Vidal, 2005 is found to be congeneric with Trichananca Blackburn, 1891, a new synonym and three new combinations are proposed: Trichananca marziae (Moore et Vidal, 2005) comb. nov., T. poqui (Guerrero et Diéguez, 2018) comb. nov., T. valenciai (Moore et Vidal, 2005) comb. nov. (all from Protoanthicus). Lectotypes are designated for Ischyropalpus maculosus (Fairmaire et Germain, 1860) and I. testaceoguttatus testaceoguttatus (Fairmaire et Germain, 1863). Hirticomus quadriguttatus (Rossi, 1792) appears to have been recently introduced to New World by human activity. Heterolobus R. A. Philippi in Philippi et Philippi, 1864, which has been originally described as Anthicidae, is moved to Salpinginae (Salpingidae). As a result of the present study, the confirmed endemism rate in Chilean Anthicidae sensu lato is about 82%.