- Academic Editors
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Background: Atrial fibrillation is one of the most common cardiac
arrhythmias. Myocardial fibrosis is closely associated with
atrial remodeling, which leads to heightened risk of atrial fibrillation. This
study aimed to explore whether forkhead box protein O3 (FOXO3a) impacts
myocardial fibrosis incidence by regulating mitophagy. Methods:
Cell viability was assessed by cell counting kit-8 (CCK-8) assays. The expression
of vimentin and cytochrome C was detected by immunofluorescence assays.
Quantitative real-time polymerase chain reaction (PCR) was used to analyze the
relative mRNA level of FOXO3a. Expression of FOXO3a, phosphorylated FOXO3a,
Collagen I, Collagen III, alpha-smooth muscle actin (