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- Academic Editor
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†These authors contributed equally.
Objective: Heme oxygenase-1 (HO-1) is a protein involved in the
inflammatory response following ischemia-reperfusion injury (IRI). Evidence
suggests that pyroptosis plays an important role in IRI. However, the underlying
mechanism between HO-1 and pyroptosis in IRI requires further investigation.
Methods: Using the “two-cuff” method, a Sprague Dawley rat model of
liver transplantation (LT) was established using livers from donors after
circulatory death. An automatic biochemical analyzer was used to detect serum
alanine transaminase (ALT) and aspartate aminotransferase (AST) levels and
evaluate liver function. Paraffin sections of the rat liver were stained with
hematoxylin-eosin (HE) to observe the degree of pathological damage. An
enzyme-linked immunosorbent assay was used to detect serum levels of
interleukin (IL)-1