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Interaction Between Anionic Liposomes and Cationic Pyridylphenylene Dendrimers

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Abstract

Complexes of a cationic pyridylphenylene dendrimer with solid and fluid anionic liposomes are prepared. Adsorption of the dendrimer on the surface of liposomes causes the neutralization of their surface charge and enlargement of the dendrimer–liposome aggregates. In interacting with fluid liposomes, the dendrimer does not induce the transition of negatively charged lipid molecules from the inner monolayer into the outer one (flip-flop). The prepared liposome–dendrimer aggregates contain 80 dendrimer molecules per liposome.

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Funding

The work was supported within the state-funded project “Modern Problems of Chemistry and Physicochemistry of High-Molecular-Weight Compounds” (project no. АААА-А16-116031050014-6).

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Correspondence to K. S. Trosheva.

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Translated by A. Kukharuk

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Trosheva, K.S., Sorokina, S.A. & Efimova, A.A. Interaction Between Anionic Liposomes and Cationic Pyridylphenylene Dendrimers. Moscow Univ. Chem. Bull. 75, 101–105 (2020). https://doi.org/10.3103/S0027131420020169

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  • DOI: https://doi.org/10.3103/S0027131420020169

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