Skip to main content
SpringerLink
Log in

Early diagnosis of lung cancer based on proteome analysis of exhaled breath condensate

  • Published:
Moscow University Chemistry Bulletin Aims and scope

Abstract

A comparative study of the exhaled-breath-condensate (EBC) proteome that was obtained for four donor groups was carried out using ion cyclotron resonance mass spectrometry with electrospray ionization. The groups included subjects with diagnosed lung cancer, chronic obstructive pulmonary disease, community-acquired pneumonia, and healthy nonsmoking control subjects. More than 300 proteins were identified, while 19 of them were found in the EBC samples of the donors who were diagnosed with lung cancer in the early stages and are potentially significant in the development of a diagnostic lung-cancer biomarker panel. It was shown that the EBC protein profiles of different donor groups can be distinguished. It may be possible to highlight a specific protein group that is typical for certain conditions/diseases of the respiratory system. Thus, the EBC analysis could be a promising non-invasive method for early diagnosis of lung cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Horváth, I., et al., Eur. Respir. J., 2005, vol. 26, no. 3, p. 523.

    Article  Google Scholar 

  2. Buszewski, B., et al., Biomed. Chromatogr., 2007, vol. 21, no. 6, p. 553.

    Article  CAS  Google Scholar 

  3. Kurova, V.S., et al., Russ. Chem. Bull., 2010, vol. 59, no. 1, p. 292.

    Article  CAS  Google Scholar 

  4. Horváth, I., et al., Eur. Respir. J., 2009, vol. 34, no. 1, p. 261.

    Article  Google Scholar 

  5. Szymanski, W.W., et al., Meas. Sci. Technol., 2002, vol. 13, no. 3, p. 303.

    Article  CAS  Google Scholar 

  6. Ferlay, J., et al., Int. J. Cancer, 2010, vol. 127, no. 12, p. 2893.

    Article  CAS  Google Scholar 

  7. Jemal, A., et al., CA: Cancer J. Clin., 2008, vol. 58, no. 2, p. 71.

    Google Scholar 

  8. Agrawal, A., et al., J. Carcinog., 2013, vol. 12, no. 1, p. 3.

    Article  Google Scholar 

  9. Reed, M.F., et al., Am. J. Surg., 2004, vol. 188, no. 5, p. 598.

    Article  Google Scholar 

  10. Cuzick, J., Eur. J. Cancer, 1999, vol. 35, no. 5, p. 685.

    Article  CAS  Google Scholar 

  11. Brothers, J.F., et al., BMC Med., 2013, vol. 11, no. 1, p. 168.

    Article  Google Scholar 

  12. Woodhead, M., et al., Clin. Microbiol. Infect., 2011, vol. 17.

  13. Kurova, V.S., et al., Clin. Chem. Lab. Med., 2009, vol. 47, no. 6, p. 706.

    Article  CAS  Google Scholar 

  14. Ryabokon’, A.M., et al, Pul’monologiya, 2014, no. 1, p. 5.

    Google Scholar 

  15. Cheng, Z., et al., J. Cancer Ther., 2011, vol. 02, no. 01, p. 1.

    Article  Google Scholar 

  16. Hoffmann, H.J., et al., Eur. Respir. J., 2008, vol. 31, no. 2, p. 380.

    Article  CAS  Google Scholar 

  17. Kurova, V.S., et al., Russ. J. Bioorg. Chem., 2011, vol. 37, no. 1, p. 48.

    Article  CAS  Google Scholar 

  18. Ghosh, R., Jana, P., and Sinha, A., Exp. Clin. Endocrinol. Diabetes, 2012, vol. 120, no. 03, p. 145.

    Article  CAS  Google Scholar 

  19. Ghosh, R., et al., Thrombosis, 2012, p. 987932.

    Google Scholar 

  20. Mikhaylova, M., et al., BMC Res. Notes, 2014, vol. 7, no. 1, p. 400.

    Article  Google Scholar 

  21. Cunningham, T.J., et al., J. Neurosci., 1998, vol. 18, no. 18, p. 7047.

    CAS  Google Scholar 

  22. Stewart, G.D., et al., Br. J. Cancer, 2008, vol. 99, no. 1, p. 126.

    Article  CAS  Google Scholar 

  23. Todorov, P., et al., Nature, 1996, vol. 379, no. 6567, p. 739.

    Article  CAS  Google Scholar 

  24. Park, S.-Y., et al., Arch. Pharm. Res., 2010, vol. 33, no. 2, p. 247.

    Article  CAS  Google Scholar 

  25. Bera, T.K., et al., Cancer Res., 2006, vol. 66, no. 1, p. 52.

    Article  CAS  Google Scholar 

  26. Wang, Q., et al., PLoS One, 2015, vol. 10, no. 4.

    Google Scholar 

  27. Huang, Y.-H., et al., PLoS One, 2013, vol. 8, no. 6.

    Google Scholar 

  28. Ezponda, T., et al., Clin. Cancer Res., 2010, vol. 16, no. 16, p. 4113.

    Article  CAS  Google Scholar 

  29. De Miguel, F.J., et al., Cancer Res., 2014, vol. 74, no. 4, p. 1105.

    Article  Google Scholar 

  30. Da Silva, M.R., et al., Biomed. Res. Int., 2015, vol. 2015, p. 150514.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    K. U. Fedorchenko, A. M. Ryabokon, A. S. Kononikhin, I. A. Popov, E. N. Nikolaev & S. D. Varfolomeev

  2. International Biotechnological Center, Moscow State University, Moscow, Russia

    K. U. Fedorchenko & S. I. Mitrofanov

  3. Department of Chemistry, Moscow State University, Moscow, Russia

    A. M. Ryabokon & I. V. Gachok

  4. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. S. Kononikhin, I. A. Popov, E. N. Nikolaev & S. D. Varfolomeev

  5. Herzen Moscow Oncology Research Institute, Moscow, Russia

    V. V. Barmin & O. V. Pikin

  6. Research Institute of Pulmonology, Federal Biomedical Agency of Russia, Moscow, Russia

    E. H. Anaev & A. G. Chuchalin

  7. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, Moscow, Russia

    A. S. Kononikhin

Authors
  1. K. U. Fedorchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Ryabokon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Kononikhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. I. Mitrofanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Barmin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. V. Pikin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. H. Anaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. I. V. Gachok
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. I. A. Popov
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. E. N. Nikolaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. G. Chuchalin
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. S. D. Varfolomeev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. M. Ryabokon.

Additional information

Original Russian Text © K.U. Fedorchenko, A.M. Ryabokon, A.S. Kononikhin, S.I. Mitrofanov, V.V. Barmin, O.V. Pikin, E.H. Anaev, I.V. Gachok, I.A. Popov, E.N. Nikolaev, A.G. Chuchalin, S.D. Varfolomeev, 2016, published in Vestnik Moskovskogo Universiteta. Khimiya, 2016, No. 2, pp. 112–119.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fedorchenko, K.U., Ryabokon, A.M., Kononikhin, A.S. et al. Early diagnosis of lung cancer based on proteome analysis of exhaled breath condensate. Moscow Univ. Chem. Bull. 71, 134–139 (2016). https://doi.org/10.3103/S0027131416020036

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S0027131416020036

Keywords

Search

Navigation