Abstract
Molecularly imprinted polymers for quercetin and the corresponding nonimprinted blank polymers (control polymers) have been synthesized using acrylamide and 2-(dimethylamino)-ethylmethacrylate as functional monomers. It has been shown that the nature of the template, the ratio of the functional monomer to template within the prepolymerization mixture, and the amount of crosslinker, which were varied at the synthesis stage, influenced on the sorption properties of molecularly imprinted polymers for quercetin. Synthesis conditions were optimized by varying the composition of the prepolymerization mixture. The sorption properties of the obtained materials have been studied. The estimation of selectivity of a sorbent with the imprints of quercetin was carried out by the example of structurally related compounds. It has been shown that the acrylamide-based polymer was able to selectively sorb quercetin, the binding sites of the quercetin being mainly of hydrophobic structure.
Similar content being viewed by others
References
Belikov, V.G., SpetsialÕaya farmatsevticheskaya khimiya, (Special Pharmaceutical Chemistry), vol. 2 of Farmatsevticheskaya khimiya, (Pharmaceutical Chemistry), Pyatigorsk, 2003, p. 457.
Manach, C., Regerat, F., Texier, O., Agullo, G., Demigne, C., and Remesy, C., Nutr. Res., 1996, vol. 16, p. 517.
Wei, B.L., Lu, C.M., Tsao, L.T., Wang, J.P., and Lin, C.N., Planta Med. A., 2001, vol. 67, p. 745.
Xie, J., Zhu, L., Luo, H., Zhou, L., Li, C., and Xu, X., J. Chromatogr. A., 2001, vol. 934, p. 1.
Tarola, A.M. and Giannetti, V., Chromatographia, 2007, vol. 65, p. 367.
Wang, S.-P. and Huang, K.-J., J. Chromatogr. A, 2004, vol. 1032, p. 273.
Molinelli, A., Weiss, R., and Mizaikoff, B., J. Agric. Food Chem., 2002, vol. 50, p. 1804.
Weiss, R., Molinelli, A., Jakusch, M., and Mizaikoff, B., Bioseparation, 2002, vol. 10, p. 379.
Hsiu, S.-L., Tsao, C.-W., Ho, H.-J., and Chao, P.-D. L., Biol. Pharm. Bull., 2001, vol. 24, p. 967.
Xie, J., Chen, L., Luo, H., Li, C., and Xu, X., J. Chromatogr. B, 2003, vol. 788, p. 233.
Alexander, C., Andersson, H.S., Andersson, L.I., Ansell, R.J., Kirsch, N., Nicholls, I.A., O’Mahony, J. and Whitcombe, M.J., Mol. Recognit., 2006, vol. 19, p. 106.
Lisichkin, G.V. and Krutyakov, Yu.A., Usp. Khim., 2006, vol. 75, p. 998.
Gendrikson, O.D., Zherdev, A.V., and Dzantiev, B.B., Usp. Biol. Khim., 2006, vol. 46, p. 149.
O’Mahony, J., Molinelli, A., Nolan, K., Smyth, M.R., and Mizaikoff, B., Biosensors and Bioelectronics, 2006, vol. 21, p. 1383.
Dmitrienko, S.G., Irkha, V.V., Kuznetsova, A.Yu, and Zolotov, Yu.A., Zh. Anal. Knim., 2004, vol. 59, p. 902 [J. Anal. Chem. (Engl. Transl.), vol. 59, no. 9, p. 808–817].
O’Mahony, J., Wei, S., Molinelli, A., and Mizaikoff, B., Anal. Chem., 2006, vol. 78, p. 6187.
Deng, Y., Fan, X., Delgado, A., Nolan, C., Furton, K., Zuo, Y., and Jones, R.D., J. Chromatogr. A, 1998, vol. 817, p. 145.
Zhang, T., Liu, F., and Chen, W., Anal. Chim. Acta., 2001, vol. 450, p. 53.
Baggiani, C., Giovannoli, C., Anfossi, L., and Tozzi, C., J. Chromatogr. A, 2001, vol. 938, p. 35.
Li, P., Rong, F., Xie, Y., Hu, V., and Yuan, C., Zh. Anal. Khim., 2004, vol.59, p. 1043 [J. Anal. Chem. (Engl. Transl.), vol. 59, no. 10, p. 939].
Lanza, F., Hall, A.J., Sellegren, B., Bereczki, A., Horvai, G., Bayoudh, S., Cormack, P.A.G., and Sherrington, D.C., Anal. Chim. Acta., 2001, vol. 435, p. 91.
Andersson, H.S., Karlsson, J.G., Piletsky, S.A., Koch-Schmidt, A.C., Mosbach, K., and Nicholls, J.A., J. Chromatogr. A, 1999, vol. 848, p. 39.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © V.A. Kudrinskaya, S.G. Dmitrienko, Yu.A. Zolotov, 2009, published in Vestnik Moskovskogo Universiteta. Khimiya, 2009, No. 3, pp. 156–163.
About this article
Cite this article
Kudrinskaya, V.A., Dmitrienko, S.G. & Zolotov, Y.A. Synthesis and study of sorption properties of molecularly imprinted polymers for quercetin. Moscow Univ. Chem. Bull. 64, 124–129 (2009). https://doi.org/10.3103/S0027131409030031
Received:
Published:
Issue Date:
DOI: https://doi.org/10.3103/S0027131409030031