Volume 31, Issue 144 (January & February 2023)                   J Adv Med Biomed Res 2023, 31(144): 57-63 | Back to browse issues page

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Shahramian I, Ostadrahimi P, Sheikh M, Nazari S, Mirzarie H, Moradi A, et al . Evaluation of S Gene Mutations in Children with Maternally Transmitted Hepatitis B. J Adv Med Biomed Res 2023; 31 (144) :57-63
URL: http://journal.zums.ac.ir/article-1-6731-en.html
Evaluation of S Gene Mutations in Children with Maternally Transmitted Hepatitis B
Iraj Shahramian1 , Pouya Ostadrahimi1 , Mahboobeh Sheikh1 , Somayeh Nazari1 , Hadi Mirzarie1 , Abdolvahab Moradi1 , Alireza Aminisefat1 , Ali Bazi1 , Feteme Parooie * 2, Masoud Tahani1
1- Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran
2- Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran , fatemeparooie@gmail.com
Abstract:   (10981 Views)

Background and Objective: Since the distribution of HBV genotypes in patients with hepatitis B indicates the predominant genotypes in specific geographical area, this study aimed to investigate the prevalence of S gene mutations in high-risk children with maternal HBV in southeastern Iran.
Materials and Methods: This cross-sectional prospective study was performed from March 2019 to March 2020. We studied 26 patients infected with hepatitis B virus through vertical route. Serological markers of HBV were tested for HBs Ag, anti-HBs, HBe Ag, anti-HBe, and anti-HBc through ELISA. HBV-positive DNA-HBV samples were examined by nested PCR. The correlation between categorical variables was estimated using Spearmen correlation coefficient.  All statistical analyses were performed using SPSS version 22 software.
Results: Our study showed that no S gene mutation occurred in studied children. However, 4 (15.4%) of the children were HBe Ag positive, while the frequency of positive HBe antibody positive in the serum of children was 18 (69.2%).
Conclusion: In general, since different types of Pre-S / S variants are predominantly identified in patients with chronic HBV that can affect the progression of liver disease, it is therefore necessary to evaluate the types of Pre-S / S variants regularly in HBV. Carriers should be identified to help discover people at higher risk for liver disease. Our study, as a single center study in southeastern Iran, indicated no mutation in this gene in hepatitis B patients.

Keywords: Mutation, Hepatitis B, HBV, Children
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✅ In general, since different types of Pre-S / S variants are predominantly identified in patients with chronic HBV that can affect the progression of liver disease, it is therefore necessary to evaluate the types of Pre-S / S variants regularly in HBV. Carriers should be identified to help discover people at higher risk for liver disease. Our study, as a single center study in southeastern Iran, indicated no mutation in this gene in hepatitis B patients.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2021/09/22 | Accepted: 2022/07/6 | Published: 2022/12/12
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