Abstract
Sjögren sendromu (SS) egzokrin bezlerin kronik, inflamatuar ve
otoimmün hastalığıdır. SS' da hastaların %20' sinde nörolojik bulgular gelişir.
Nörolojik bulgular göz ve ağız kuruluğu gibi sicca semptomları ortaya çıkmadan
önce de görülebilir. Periferik sinir sistemi tutulumu (PSS) %15, santral sinir
sistemi (SSS) tutulumu %5 oranında görülür. SSS tutulumu, PSS tutulumuna göre
çok daha az görülür. Bu vakada, transvers myelit ile prezente olan, serum anti
Ro-SSA/anti La-SSB antikorları negatif olan ve sicca bulguları olmayan bir
sjögren sendromu ele alınmıştır.
Keywords
References
- 1. Delalande S, de Seze J, Fauchais AL, Hachulla E, Stojkovic T, Ferriby D, Dubucquoi S, Pruvo JP, Vermersch P, Hatron PY. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore). 2004;83(5):280-91.
- 2. Tobón GJ, Pers JO, Devauchelle-Pensec V, Youinou P. Neurological Disorders in Primary Sjögren's Syndrome.Autoimmune Dis. 2012;2012:645967.
- 3. Gono T, Kawaguchi Y, Katsumata Y, Takagi K, Tochimoto A, Baba S, Okamoto Y, Ota Y, Yamanaka H. Clinical manifestations of neurological involvement in primary Sjögren’s syndrome. Clin Rheumatol. 2011;30(4):485-90.
- 4. Fayyaz A, Kurien BT, Scofield RH. Autoantibodies in Sjögren's Syndrome. Rheum Dis Clin North Am. 2016;42(3):419-34.
- 5. Berkowitz AL, Samuels MA. The neurology of sjögren’s syndrome and the rheumatology of peripheral neuropathy and myelitis . Pract Neurol 2014;14:14-22.
- 6. Carvajal Alegria G, Guellec D, Mariette X, Gottenberg JE, Dernis E, Dubost JJ, Trouvin AP, Hachulla E, Larroche C, Le Guern V, Cornec D, Devauchelle-Pensec V, Saraux A. Epidemiology of neurological manifestations in Sjögren's syndrome: data from the French ASSESS Cohort. RMD Open. 2016 Apr 20;2(1):e000179.
- 7. Birnbaum J. Peripheral nervous system manifestations of Sjögren syndrome: clinical patterns, diagnostic paradigms, etiopathogenesis, and therapeutic strategies.Neurologist. 2010;16(5):287-97.
Abstract
Sjögren’s syndrome (SS) is a chronic inflammatory disorder of exocrine
glands with autoimmune etiology. Neurological symptoms occur in approximately
20% of patients with Sjögren’s syndrome.
Neurological symptoms may occur before the onset of sicca symptoms such
as; dry eyes and dry mouth. The prevalence of peripheral and central
neurological manifestations in Sjögren
syndrome are about 15% and 5% respectively. CNS involvement is much less common
than peripheral nervous system involvement. In this case, our patient presented
symptoms of transverse myelitis; however, the serum Anti-Ro/SSA and anti-La/SSB
antibodies were negative and there were no dry eyes and dry mouth.
Keywords
References
- 1. Delalande S, de Seze J, Fauchais AL, Hachulla E, Stojkovic T, Ferriby D, Dubucquoi S, Pruvo JP, Vermersch P, Hatron PY. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore). 2004;83(5):280-91.
- 2. Tobón GJ, Pers JO, Devauchelle-Pensec V, Youinou P. Neurological Disorders in Primary Sjögren's Syndrome.Autoimmune Dis. 2012;2012:645967.
- 3. Gono T, Kawaguchi Y, Katsumata Y, Takagi K, Tochimoto A, Baba S, Okamoto Y, Ota Y, Yamanaka H. Clinical manifestations of neurological involvement in primary Sjögren’s syndrome. Clin Rheumatol. 2011;30(4):485-90.
- 4. Fayyaz A, Kurien BT, Scofield RH. Autoantibodies in Sjögren's Syndrome. Rheum Dis Clin North Am. 2016;42(3):419-34.
- 5. Berkowitz AL, Samuels MA. The neurology of sjögren’s syndrome and the rheumatology of peripheral neuropathy and myelitis . Pract Neurol 2014;14:14-22.
- 6. Carvajal Alegria G, Guellec D, Mariette X, Gottenberg JE, Dernis E, Dubost JJ, Trouvin AP, Hachulla E, Larroche C, Le Guern V, Cornec D, Devauchelle-Pensec V, Saraux A. Epidemiology of neurological manifestations in Sjögren's syndrome: data from the French ASSESS Cohort. RMD Open. 2016 Apr 20;2(1):e000179.
- 7. Birnbaum J. Peripheral nervous system manifestations of Sjögren syndrome: clinical patterns, diagnostic paradigms, etiopathogenesis, and therapeutic strategies.Neurologist. 2010;16(5):287-97.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Case Report |
| Authors | |
| Publication Date | July 15, 2017 |
| Submission Date | February 22, 2017 |
| Acceptance Date | April 2, 2017 |
| Published in Issue | Year 2017 Volume: 1 Issue: 2 |
This Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.