Determination of Mesalazine Using Terbium Rare Earth Ions as a Fluorescence Probe

DOI

10.2991/icmsa-15.2015.10How to use a DOI?

Keywords

Ulcerative Colitis, Mesalazine, Terbium Rare Earth, Fluorescent, Content Determination.

Abstract

Ulcerative colitis is chronic nonspecific colitis. Now,the main first-line drugs are preparations with mesalazine. Chemical name of mesalazine is 5- aminosalicylic acid (5-ASA), which one of colon target drugs has function of anti-inflammatory by inhibit process of leukotriene, prostaglandin E(PG) and free radical. Comparing with traditional SASP drugs used for treating colitis, 5-ASA has character of less harmful to body. In recent decade, mechanism and preparation of the mesalazine have attended at home and abroad. This paper established the rare earth fluorescence probe, which a new kind of technology for drug determination, contenting 5-ASA. It is more convenient, shortcut, accuracy than common methods of titration, ultraviolet spectrophotometry and high-performance liquid chromatography. According this, it provided a new and viable method of determination of 5-ASA. This method also can assist to research 5-ASA in the subjects that biopharmaceutical analysis, pharmacokinetics and clinical pharmacy, required strict experiment conditions.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yu-Guang Lv
AU  - Di Song
AU  - Du A
AU  - Ji-Hui Zheng
AU  - Hong-Bing Gao
AU  - Xiao-Li Qi
AU  - Jiang Wu
AU  - Zhong-Ping Gong
AU  - Jie Teng
PY  - 2014/06
DA  - 2014/06
TI  - Determination of Mesalazine Using Terbium Rare Earth Ions as a Fluorescence Probe
BT  - Proceedings of the 2015 International Conference on Material Science and Applications
PB  - Atlantis Press
SP  - 51
EP  - 56
SN  - 2352-541X
UR  - https://doi.org/10.2991/icmsa-15.2015.10
DO  - 10.2991/icmsa-15.2015.10
ID  - Lv2014/06
ER  -