IMR Press / FBL / Volume 17 / Issue 7 / DOI: 10.2741/4059

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Obesity and gastric cancer
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1 Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
2 Storr Liver Unit, Westmead Millennium Institute, The University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
Front. Biosci. (Landmark Ed) 2012, 17(7), 2383–2390; https://doi.org/10.2741/4059
Published: 1 June 2012
Abstract

Obesity is an important public health problem worldwide. It increases the risk of many chronic diseases such as diabetes and cardiovascular diseases. Meanwhile, obesity is a major risk factor for several types of cancer including gastric cancer. Possible mechanisms linking obesity with gastric cancer may include obesity associated gastro-oesophageal reflux, insulin resistance, altered levels of adiponectin, leptin, ghrelin, and an abnormally increased blood level of insulin-like growth factor (IGF). Helicobacter pylori (H. pylori) infection is a well-recognized risk factor for peptic ulcer and gastric cancer. Recent studies have revealed an increased prevalence of H. pylori infection in obese patients, providing another clue for the increased incidence of gastric cancer in obese population. If this connection can be confirmed in animal models and a large cohort of patients, then eradicating H. pylori together with life style modification in obese individuals may help prevent the development of gastric cancer in the increasingly obese population.

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