The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
Sclerosing Hepatocellular Carcinoma with Hypercalcemia
A Case Report
FUMIHIKO YAMASHITA, TADASHI IWAO, TAKUJI TORIMURA, MASATOSHI TANAKA, KENJI HIRAI, MASAHIDE ABE, ATSUSHI TOYONAGA, SHIGETAKA SUGIHARA, MASAMICHI KOJIRO, KYUICHI TANIKAWA
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Keywords: sclerosing hepatocellular carcinoma, hypercalcemia, electron dense granules, paraneoplastic syndrome, intrabile duct tumor growth
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1992 Volume 39 Issue 2 Pages 113-116

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Abstract

A case of sclerosing hepatocellular carcinoma (SHCC) with hypercalcemia was reported. Clinical studies revealed a tumor at the liver hilum with invasion into the bile duct. Light microscopy of the tumor disclosed a moderately differentiated hepatocellular carcinoma (HCC) of the trabecular type with diffuse fibrous stroma. Abundant dense granules were observed in the cytoplasm of the tumor cells with electron microscopy. The elevated serum calcium (13.9 mg/dl) returned to the normal range after resection of the tumor.

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