Effect of Adriamycin on Lipid Peroxide, Glutathione Peroxidase and Respiratory Responses of Mitochondria from the Heart, Liver and Kidney

SUNG BOO MOON; KIMINORI KAJIYAMA; YUJI HINO; MASAYASU SUGIYAMA; RYOHEI OGURA

doi:10.2739/kurumemedj.30.1

SUNG BOO MOON, KIMINORI KAJIYAMA, YUJI HINO, MASAYASU SUGIYAMA, RYOHEI OGURA

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Keywords: adriamycin, cardiotoxicity, mitochondria, lipid peroxide, glutathione peroxidase, respiratory response

JOURNAL FREE ACCESS

1983 Volume 30 Issue 1 Pages 1-4

DOI https://doi.org/10.2739/kurumemedj.30.1

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Abstract

Administration of adriamycin induced an elevation of lipid peroxide content, a decrease of glutathione peroxidase activity and a disturbance of the respiratory responses in heart mitochondria. Cardiac mitochondria were much more sensitive to adriamycin, than mitochondria of the liver and kidney.

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