Research Progress on the Relationship between Vascular Aging and Hypertension
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Keywords

Vascular aging
Hypertension
Mechanism

DOI

10.26689/par.v5i6.2796

Submitted : 2021-10-31
Accepted : 2021-11-15
Published : 2021-11-30

Abstract

Vascular aging refers to the structural and functional changes of the arterial wall with age. Vascular aging plays an important role in elderly diseases, such as hypertension. Therefore, the relationship between vascular aging and hypertension has attracted extensive attention. This article mainly reviews the mechanism of vascular aging and its influence on hypertension, so as to provide new ideas and directions for the research and prevention of hypertension.

References

Tao L, 2011, Study on the Mechanism of TCM Nourishing Qi and Promoting Blood Circulation Delaying Aging and Vascular Aging Induced by Hypertension. China Academy of Chinese Medical Sciences.

Wang Y, 2012, Study on the Correlation between Hypertension and Vascular Aging. Jilin Medical Journal, 33(24): 5185.

Buford TW, 2016, Hypertension and Aging. Ageing Res Rev, 26: 96-111. DOI: 10.1016/j.arr.2016.01.007

Lanzer P, Boehm M, Sorribas V, et al., 2014, Medial Vascular Calcification Revisited: Review and Perspectives. Eur Heart J, 35(23): 1515-1525. DOI: 10.1093/eurheartj/ehul63

Zhang L, Zhang C, 2016, Vascular Calcification and Vascular Aging. Chinese Journal of Geriatrics, 35(10): 1046-1050.

Leopold JA, 2014, MicroRNAs Regulate Vascular Medial Calcification. Cells, 3(4): 963-980. DOI: 10.3390/cells3040963

Otsuka F, Sakakura K, Yahagi K, et al., 2014, Has Our Understanding of Calcification in Human Coronary Atherosclerosis Progressed? Arterioscler Thromb Vasc Biol, 34(4): 724-736. DOI: 10.1161/ATVBAHA.113.302642

Jaminon A, Reesink K, Kroon A, et al., 2019, The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes. Int J Mol Sci, 20(22): 5694. DOI: 10.3390/ijms20225694

Zhang L, Wang Y, Liu Y, et al., 2016, Inflammation and Vascular Aging. Chinese Journal of Geriatrics, 35(10): 1038-1041.

Wang M, Monticone RE, Lakatta EG, 2014, Proinflammation of Aging Central Arteries: A Mini Review. Gerontology, 60(6): 519-529. DOI: 10.1159/000362548

Wang M, Jiang L, Monticone RE, et al., 2014, Proinflammation: The Key to Arterial Aging. Trends Endocrinol Metab, 25(2): 72-79. DOI: 10.1016/j.tem.2013.10.002

Wang M, Khazan B, Lakatta EG, 2010, Central Arterial Aging and Angiotensin II Signaling. Curr Hypertens Rev, 6(4): 266-281. DOI: 10.2174/157340210793611668

Touyz RM, Alves-Lopes R, Rios FJ, et al., 2018, Vascular Smooth Muscle Contraction in Hypertension. Cardiovasc Res, 114: 529-539. DOI: 10.1093/cvr/cvy023

Zhu Y, He L, Qu J, et al., 2018, Regulation of Vascular Smooth Muscle Cell Stiffness and Adhesion by [Ca2+]i: An Atomic Force Microscopy-Based Study. Microsc Microanal, 24: 708-712. DOI: 10.1017/S1431927618015519

Sehgel NL, Zhu Y, Sun Z, et al., 2013, Increased Vascular Smooth Muscle Cell Stiffness: A Novel Mechanism for Aortic Stiffness in Hypertension. Am J Physiol Heart Circ Physiol, 305: H1281-H1287. DOI: 10.1152/ajpheart.00232.2013

Guo H, Song W, Zhang M, et al., 2013, Study on the Correlation between Essential Hypertension and Vascular Aging. Practical Preventive Medicine, 20(03): 370-371.