International Journal of New Developments in Engineering and Society, 2021, 5(1); doi: 10.25236/IJNDES.2021.050109.
Tiange Chang
College of Life Sciences, Lanzhou University, Lanzhou, 730000, China
Phosphorus flame retardants are harmful to human body, but the research on them is not enough. This study focuses on the damage mechanism of phosphorus flame retardant to human body by selecting Chinese hamster ovary cells which similarity of DNA sequences of human is ninety-five percent, mainly from the aspects of calcium ion and caspase. The possible results of the experiment are listed in this research.
phosphorus flame retardant, caspase, calcium
Tiange Chang. Mechanism of Flame Retardants Causing Damage to Chinese Hamster Ovary Cells. International Journal of New Developments in Engineering and Society (2021) Vol.5, Issue 1: 44-46. https://doi.org/10.25236/IJNDES.2021.050109.
[1] EPA, I., 2007. Report on Alternatives to the Flame Retardant DecaBDE: Evaluation of Toxicity, Availability, Affordability, and Fire Safety Issues. A Report to the Governor and the General Assembly.
[2] Hausherr, V., van Thriel, C., Krug, A., Leist, M., Scho€bel, N., 2014. Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-o- cresyl phosphate (TOCP) at non-cytotoxic concentrations. Toxicol. Sci. 142 (1), 274e284.
[3] Dishaw, L.V., Powers, C.M., Ryde, I.T., Roberts, S.C., Seidler, F.J., Slotkin, T.A., Stapleton, H.M., 2011. Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicol. Appl. Pharm. 256, 281e289.
[4] Jin, Y., Chen, G., Fu, Z., 2015. Effects of TBEP on the induction of oxidative stress and endocrine disruption in Tm3 Leydig cells. Environ. Toxicol. 31, 1276.
[5] Stine, K.E., Brown, T.M., 2015. Principles of Toxicology, third ed. Crc Press.
[6] Bova, M.P., Tam, D., McMahon, G., Mattson, M.N., 2005. Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells. Toxicol. Lett. 155, 41e50.
[7] Zou, C., Kou, R., Gao, Y., Xie, K., Song, F., 2013. Activation of mitochondria-mediated apoptotic pathway in tri-ortho-cresyl phosphate-induced delayed neuropathy. Neurochem. Int. 62, 965e972.
[8] Carlson, K., Jortner, B.S., Ehrich, M., 2000. Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells. Toxicol. Appl. Pharm. 168, 102e113.
[9] Karami-Mohajeri, S., Abdollahi, M., 2013. Mitochondrial dysfunction and organo-phosphorus compounds. Toxicol. Appl. Pharm. 270, 39e44.
[10] Bergsbaken, T., Fink, S.L., Cookson, B.T., 2009. Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7, 99e109.