Case Report
Year 2020,
Volume: 22 Issue: 1, 134 - 138, 30.04.2020
Abstract
Acromegaly is a rare metabolic disorder that develops with over secretion of growth hormone (GH) after the epiphyseal plates are closed. Acromegaly starts insidiously and progresses very slowly. Signs and symptoms of growth hormone elevation may not be noticed for years. Jaw enlargement, swelling of the hands and feet, prominent facial bones, facial roughness, nasal enlargement, tongue enlargement, deepening of the voice, snoring and sleep apnea, skin thickening, excessive and malodorous sweating are some of the clinical changes. Changes in acromegaly such as macroglossia, diastemas, class III malocclusion, condylar growth, mandibular enlargement and thickening of facial tissues are familiar for dentists. Dental clinicians can play an important role in the diagnosis of acromegaly or other systemic diseases with careful examination and history.
References
- 1. Kashyap RR, Babu GS, Shetty SR. Dental patient with acromegaly: a case report. J Oral Sci. 2011;53(1):133-6.
- 2. Ayuk J, Sheppard MC. Growth hormone and its disorders. Postgrad Med J. 2006;82(963):24-30.
- 3. Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009;119(11):3189-202.
- 4. Gosau M, Vogel C, Moralis A, Proff P, Kleinheinz J, Driemel O. Mandibular prognathism caused by acromegaly- a surgical orthodontic case. Head Face Med. 2009;5(1):16. Doi: 10.1186/1746-160X-5-16.
- 5. Grottoli S, Gasco V, Ragazzoni F, Chigo E. Hormonal diagnosis of GH hyper¬secrotory states. J Endocrinol Invest. 2003;26(10):27-35.
- 6. Lugo G, Pena L, Cordido F. Clinical manifestations and diagnosis of acromegaly. Int J Endocrinol. 2012;2012(1):1-10.
- 7. Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;25:3-17. doi: 10.1186/1750-1172-3-17.
- 8. Cawson RA, Odell EW. Essential of Oral Pathology and Oral Medicine. 6th ed. London. Churchill Livingstone Publisher, 1998.
- 9. Arosio M, Cannova S, Epaminonda P, Ronchi C, Chiodini I, Adda G. Therapy for the syndromes of GH excess. J Endocrinal Invest. 2003;26(10 Suppl):36-43.
- 10. Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab. 2006;91(12):4769-75.
- 11. Katznelson L, Laws Jr ER, Melmed S, Molitch ME, Murad MH, Utz A et al. Endocrine Society. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-51.
Year 2020,
Volume: 22 Issue: 1, 134 - 138, 30.04.2020
Abstract
Akromegali, epifiz plaklarının kapanmasından sonra aşırı büyüme hormonu (GH) salgılanmasıyla gelişen nadir bir metabolik hastalıktır. Akromegali sessizce başlar ve çok yavaş ilerler. Büyüme hormonu artışı belirtileri ve semptomları yıllarca fark edilmeyebilir. Çene büyümesi, el ve ayaklarda şişlik, yüz kemiklerinde belirginlik, yüzde kabalık, burun büyümesi, dil büyümesi, sesin kalınlaşması, horlama ve uyku apnesi, cilt kalınlaşması, aşırı ve kötü kokulu terleme klinik değişikliklerden bazılarıdır. Makroglossi, diastemalar, sınıf III maloklüzyon, kondiler büyüme, mandibular genişleme ve fasiyal dokuların kalınlaşması gibi değişiklikler diş hekimliği ile yakından ilişkilidir. Diş klinisyenleri, dikkatli muayene ve anamnez ile akromegali veya diğer sistemik hastalıkların tanısında önemli bir rol oynayabilir.
References
- 1. Kashyap RR, Babu GS, Shetty SR. Dental patient with acromegaly: a case report. J Oral Sci. 2011;53(1):133-6.
- 2. Ayuk J, Sheppard MC. Growth hormone and its disorders. Postgrad Med J. 2006;82(963):24-30.
- 3. Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009;119(11):3189-202.
- 4. Gosau M, Vogel C, Moralis A, Proff P, Kleinheinz J, Driemel O. Mandibular prognathism caused by acromegaly- a surgical orthodontic case. Head Face Med. 2009;5(1):16. Doi: 10.1186/1746-160X-5-16.
- 5. Grottoli S, Gasco V, Ragazzoni F, Chigo E. Hormonal diagnosis of GH hyper¬secrotory states. J Endocrinol Invest. 2003;26(10):27-35.
- 6. Lugo G, Pena L, Cordido F. Clinical manifestations and diagnosis of acromegaly. Int J Endocrinol. 2012;2012(1):1-10.
- 7. Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;25:3-17. doi: 10.1186/1750-1172-3-17.
- 8. Cawson RA, Odell EW. Essential of Oral Pathology and Oral Medicine. 6th ed. London. Churchill Livingstone Publisher, 1998.
- 9. Arosio M, Cannova S, Epaminonda P, Ronchi C, Chiodini I, Adda G. Therapy for the syndromes of GH excess. J Endocrinal Invest. 2003;26(10 Suppl):36-43.
- 10. Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab. 2006;91(12):4769-75.
- 11. Katznelson L, Laws Jr ER, Melmed S, Molitch ME, Murad MH, Utz A et al. Endocrine Society. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-51.
There are 11 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | April 30, 2020 |
| Submission Date | November 18, 2019 |
| Published in Issue | Year 2020 Volume: 22 Issue: 1 |
Cite
Bu Dergi, Kırıkkale Üniversitesi Tıp Fakültesi Yayınıdır.