Chemokines in inflammatory and immune diseases

Kouji Matsushima; Yuya Terashima; Etsuko Toda; Francis Shand; Satoshi Ueha

doi:10.2492/inflammregen.31.11

Review Article

Chemokines in inflammatory and immune diseases

Kouji Matsushima, Yuya Terashima, Etsuko Toda, Francis Shand, Satoshi Ueha

Author information

Keywords: Chemokines, inflammation, immunity, therapy

JOURNAL FREE ACCESS

2011 Volume 31 Issue 1 Pages 11-22

DOI https://doi.org/10.2492/inflammregen.31.11

Details

Abstract

Nearly two decades have passed since our discovery of the prototypic chemokines, a neutrophil chemotactic factor interleukin 8 (IL 8, CXCL8) and monocyte chemotactic factor MCAF/MCP-1 (CCL2) at the National Cancer Institute, USA. The characterization of chemokines has revealed the molecular mechanisms underlying specific leukocyte subset infiltration into inflammatory tissues, previously a long-standing enigma in inflammation research. In this review we briefly recount the chronology of chemokine research, then overview chemokine receptor signal transduction systems, chemokines in inflammation and immunity, chemokines in HIV infection and cancer, and the current status of therapeutic approaches targeting chemokines and their receptors.

Corresponding author

Register with J-STAGE for free!