Serum level of estrogen in Iranian patients with oral lichen planus
, , and | Jun 30, 2021
Article Category: Brief communication (original)
Published Online: Jun 30, 2021
Page range: 145 - 150
DOI: https://doi.org/10.2478/abm-2021-0018
Keywords
© 2021 Narges Gholizadeh et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Oral lichen planus (OLP) is one of the most common diseases in the oral cavity and has a chronic inflammatory nature. The etiology of this disease remains unclear. OLP is more prevalent in women, but to our knowledge, no study yet evaluated estrogen levels in women with OLP.
Objectives
To determine the serum level of estrogen in female patients with OLP.
Methods
This case–control observational study was conducted in patients who were referred to the Department of Oral and Maxillofacial Medicine at the Tehran University of Medical Sciences. After clinical and histopathological confirmation of OLP diagnosis, and according to exclusion and inclusion criteria, 47 women with OLP and 47 healthy women (10 premenopausal and 37 postmenopausal) were included, as case and control groups, respectively. We obtained blood samples (5 mL) from each participant to measure the serum level of 17β-estradiol. Data were analyzed by Spearman rank correlation coefficients and a two-way analysis of variance with Bonferroni post hoc tests.
Results
Serum estrogen level in women with OLP was significantly higher than that in healthy women (
Conclusion
OLP, like other autoimmune diseases, is affected by the serum level of sex hormones such as estrogen.