REVIEW   

Minerva Endocrinology 2024 March;49(1):85-99

DOI: 10.23736/S2724-6507.23.04030-7

Copyright © 2023 EDIZIONI MINERVA MEDICA

language: English

The development and evolution of insulin pumps: from early beginnings to future prospects

Francesco A. MAZZOTTA ¹, Lorenzo LUCACCINI PAOLI ¹ ✉, Alessandro RIZZI ², Linda TARTAGLIONE ², Maria L. LEO ¹, Federica CRISTALLO ², Valentina POPOLLA ², Mauro DI LEO ², Alfredo PONTECORVI ¹, Dario PITOCCO ²

¹ Department of Endocrinology, Catholic University of the Sacred Heart, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy; ² Diabetes Care Unit, Catholic University of the Sacred Heart, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy

Diabetes technology has proliferated extensively over the past few decades with vast ameliorations in glucose monitoring and in insulin delivery systems. From a treatment based on daily insulin injections, we have moved to increasingly advanced technologies. Despite such advancements which have allowed better glycemic control, decreased diabetes-related complications, and improved the quality of life among diabetic patients, it has left many individuals unsatisfied with the current rate of commercial artificial pancreas development, stemming the need for further research into novel technologies. Accordingly, the Juvenile Diabetes Research Foundation has marked three generations for the development of an artificial pancreas comprising historical landmarks and future prospects which aim to produce an advanced technological system that attempts to mimic the endogenous pancreas, eliminating the need for user input. This review presents a synopsis of the development and evolution of insulin pumps, starting with the earliest technologies available such as continuous subcutaneous insulin infusion and continuous glucose monitoring as separate components, to currently available integrated advanced closed-loop hybrid systems and possible future technologies. The aim of the review is to provide insight of the advantages and limitations of past and currently available insulin pumps with the hope of driving research into novel technologies that attempt to mimic endogenous pancreatic function as closely as possible.

KEY WORDS: Diabetes mellitus; Insulin infusion systems; Blood glucose self-monitoring