ORIGINAL ARTICLE   

Journal of Neurosurgical Sciences 2020 October;64(5):446-51

DOI: 10.23736/S0390-5616.17.04102-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Spinal meningiomas: 61 cases with predictors of early postoperative surgical outcomes

Ahmed B. BAYOUMI ¹, Yosef LAVIV ², Ceren N. KARAALI ¹, Kemal ERTILAV ³, Umit KEPOGLU ¹, Zafer O. TOKTAS ¹, Deniz KONYA ¹, Ekkehard M. KASPER ² ✉

¹ Department of Neurosurgery, Medical Park of Goztepe Hospital, Bahcesehir University School of Medicine, Istanbul, Turkey; ² Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; ³ Department of Neurosurgery, Suleyman Demirel University, Isparta, Turkey

BACKGROUND: Spinal meningiomas are benign, well-circumscribed and slowly-growing intradural tumors that compress the spinal cord. Hereby, a retrospective review of 61 spinal meningioma cases evaluated in terms of demographic, clinical, pathological and radiological features to predict the early postoperative functional outcomes.
METHODS: Patients’ records and MRI images of all the histologically confirmed spinal meningioma cases that underwent surgical resection at two university hospitals from January 2005 to June 2016 were retrospectively reviewed. Demographic data, clinical findings, radiological features and pathology reports were reviewed. Univariate and multivariate logistic regression analyses were used to evaluate the impact of each factor on the early 3-month post-surgical functional outcome. A receiver operating characteristic (ROC) curve was used to predict the power of the model.
RESULTS: Sixty-one cases of spinal meningiomas were operated: 13 males (21%) and 48 females (79%). Mean age was 60.5 years and ranged from 24 to 92 years. Patients presented with back pain (57%), motor deficits (47.5%), sensory deficits (18%) and sphincteric dysfunction (11.5%). One case (1.6%) showed an additional extradural growth. There were 40 thoracic, nine cervical, five cervicothoracic, five thoracolumbar, and two lumbar cases. Only four cases (6.6%) showed atypical pathological features (WHO grade II). At 3-month follow-up, 46 patients (75.4%) had either functionally improved or remained stable. Fifteen patients (24.6%) had “worse” functional outcome. Three variables showed statistically significant odds ratio for improved outcomes (OR): pre-surgical motor deficit (OR=5; P=0.005); presurgical sensory disturbance (OR=3.5; P=0.026); pre-surgical myelopathy (OR=3.5; P=0.026). Multivariate analysis showed increased OR for cross-sectional ratio, pre-surgical myelopathy, pre-surgical radiculopathy and non-cervical location of tumor (1.59, 3.46, 3.2, 1.63/3.56, respectively). Although none has reached statistical significance (P>0.05), the receiver operating characteristic (ROC) curve showed an area under the curve (AUC) of 0.74.
CONCLUSIONS: The independent predictors of the early postoperative functional outcomes of spinal meningioma resections may include pre-surgical motor deficit, sensory deficit and myelopathy.

KEY WORDS: Spine; Meningioma; Spinal cord neoplasms