JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Publication history |
Reprints |
Permissions |
Cite this article as |
Share |
YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
ORIGINAL ARTICLE
Minerva Anestesiologica 2023 December;89(12):1099-104
DOI: 10.23736/S0375-9393.23.17490-6
Copyright © 2023 EDIZIONI MINERVA MEDICA
language: English
Serum neurofilament light chain as an early diagnostic biomarker for critical illness polyneuropathy
Gudrun ZULEHNER 1, Christian SCHÖRGENHOFER 2, Paulus ROMMER 1, Marieke MERRELAAR 3, Sybille BEHRENS 3, Markus PONLEITNER 1, Harald HERKNER 3, Thomas STAUDINGER 4, Christian ZAUNER 5, Dominik ROTH 3, Patrick ALTMANN 1, Calvin Lukas KIENBACHER 3 ✉
1 Department of Neurology, Medical University of Vienna, Vienna, Austria; 2 Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; 3 Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria; 4 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria; 5 Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
BACKGROUND: Critical illness polyneuropathy (CIP) commonly occurs in critical care unit (CCU) patients, but timely diagnosis can be challenging. Therefore, new biomarkers, such as serum neurofilament light chain (sNfL), could help to improve early identification of patients with this condition.
METHODS: CIP was diagnosed or excluded with neurological assessment and nerve conduction measurement in a prospective study of CCU patients. sNfL and secondary predictors for neuropathy (neuron-specific enolase (NSE), S100, folic acid, and vitamin B
RESULTS: Nineteen patients met the inclusion criteria. CIP was considered definitely or most likely present in seven (37%, cases) and definitely or most likely absent in 12 individuals (63%, controls). At admission, sNfL levels were significantly higher in the cases than in the controls: 405 (IQR 77 to 835) vs. 27 (IQR 12 to 90) pg/mL; difference of medians 375, 95% confidence interval [14, 736], pg/mL; P=0.04. We found no significant differences regarding the secondary predictors at baseline. Cases had longer durations of CCU stay (median 19 (IQR 11 to 44) vs. 8 (IQR five to ten) and increased mortality (57% vs. 33% deceased) compared to controls.
CONCLUSIONS: Levels of serum neurofilament light chain are higher in patients who develop CIP soon after CCU admission and might be helpful in identifying those individuals early.
KEY WORDS: Polyneuropathies; Critical care; Biomarkers