REVIEW   

Minerva Medica 2018 April;109(2):126-40

DOI: 10.23736/S0026-4806.17.05403-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Renal disease in patients with celiac disease

Boonphiphop BOONPHENG ¹, Wisit CHEUNGPASITPORN ², Karn WIJARNPREECHA ³ ✉

¹ Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA; ² Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA; ³ Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA

Celiac disease, an inflammatory disease of small bowel caused by sensitivity to dietary gluten and related protein, affects approximately 0.5-1% of the population in the Western world. Extra-intestinal symptoms and associated diseases are increasingly recognized including diabetes mellitus type 1, thyroid disease, dermatitis herpetiformis and ataxia. There have also been a number of reports of various types of renal involvement in patients with celiac disease including diabetes nephropathy, IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, nephrotic syndrome related to malabsorption, oxalate nephropathy, and associations of celiac disease with chronic kidney disease and end-stage kidney disease. This review aims to present the current literature on possible pathologic mechanisms underlying renal disease in patients with celiac disease.

KEY WORDS: Celiac disease - Kidney diseases - Glomerulonephritis