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CASE REPORT
Giornale Italiano di Dermatologia e Venereologia 2019 April;154(2):205-8
DOI: 10.23736/S0392-0488.17.04942-2
Copyright © 2014 EDIZIONI MINERVA MEDICA
language: English
Late onset warfarin-induced skin necrosis
Chongmei XIN, Dongyan HU, Ming LI ✉
Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China
The incidence of warfarin-induced skin necrosis (WISN) is rare. The majority of WISN cases usually appear between 3 and 6 days after the initiation of warfarin therapy. Here we report a late-onset case of WISN that occurred in a 52-year-old man 4 years after the initiation of therapy. The skin lesions in the patient were associated with acquired deficiency of protein C and protein S and abnormal liver function.
KEY WORDS: Late onset disorders - Necrosis - Skin - Warfarin - Protein C deficiency - Protein S deficiency
