ORIGINAL ARTICLE   Free access

Minerva Anestesiologica 2017 March;83(3):274-81

DOI: 10.23736/S0375-9393.16.11406-3

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Comparison of two different forms of sevoflurane for anesthesia maintenance and recovery

Yonca YANLI ¹, Mehtap OZDEMİR ¹, Nurten BAKAN ¹, Cafer T. YURUK ¹, Ahmet YILDIRIM ¹, Ali O. CETINKAYA ² ✉

¹ Department of Anesthesiology and Reanimation, Umraniye Training and Research Hospital, Istanbul, Turkey; ² Department of Anesthesiology and Reanimation, Beykoz State Hospital, Istanbul, Turkey

BACKGROUND: Sevoflurane is a commonly used inhalation agent. There are two forms of sevoflurane in Turkey. The aim of this study was to evaluate the effects of original versus generic sevoflurane products on hemodynamics, time to reach 1 MAC level, inspired and expired sevoflurane levels and postoperative recovery profile.
METHODS: Seventy patients undergoing general anesthesia were divided into two groups as Group Sevo or Group Sojo. After intravenous induction of anesthesia (with the same drugs in both groups), inhalation anesthetic was started. Hemodynamic parameters, Bispectral index (BIS), time to reach 1MAC level, inspired and expired sevoflurane levels, percent vaporizer concentration of sevoflurane, additional remifentanil doses were recorded. In the awakening period, decreasing times of MAC 0.5, 0.4, 0.3, BIS levels, sedation-agitation and Aldrete scores were recorded.
RESULTS: The time to reach 1MAC level was shorter in Group Sevo than in Group Sojo (P=0.01). The fractions of inspired sevoflurane levels were higher at 4, 6, 8, 10, 15, 30, 35, and 45 minutes, the fractions of expired sevoflurane levels were higher at 4, 6, 8, 10, 15, and 20 minutes in Group Sevo (P<0.05). In the awakening period and postoperatively, there were no differences in recorded parameters between the groups.
CONCLUSIONS: Although there are differences in maintenance period of the anesthesia, the two products seem to be comparable routine anesthesia practice. But further studies are needed to enhance our knowledge.

KEY WORDS: Inhalation anesthetics - Sevoflurane - General anesthesia - Consciousness monitors