The wettability of sintered nanocrystalline oxide powders (CeO₂, TiO₂, Y₃Al₅O₁₂, and ZrO₂-yttria stabilized) and Al₂O₃ basis powder (60–70% purity) (product originated in the secondary aluminium production, composed mainly of nano and micrometric aluminium oxide) by liquid Armco Fe and by 22CrNiMoV5-3 steel grade was studied using sessile drop wettability technique. The powders were pressed and sintered under different pressures, heating rates and holding times. The later grinding and polishing surface treatments were characterized by infinite focus microscope. The wetting experiments were carried out under pure Ar atmosphere. A small piece of Armco Fe and steel grade was melted on sintered nano oxides, heating up to 1600°C with a holding time of 10 minutes for each experiment. The contact angles were measured and chemical analyses were conducted on tested samples to characterize the wetting reactions. It was found that sintered nano TiO₂ not only suffered considerable wetting by Armco Fe and 22CrNiMoV5-3 steel in both cases, but also reacted with the substrate to form ilmenite and pseudobrookite. The CeO₂ substrate and Armco Fe system also showed good wetting behavior. In general terms, it was concluded that wettability was affected by substrate chemical composition, and surface characteristics by sintering conditions. The preliminary results of this investigation may help to determine the suitability of the nanoparticle to be added in a liquid iron based matrix in order to influence the microstructure evolution improving mechanical properties by a fine distribution in the metallic alloy.