Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?
DOI:
https://doi.org/10.2340/actadv.v102.2048Keywords:
COVID-19 vaccine, adverse drug reaction, pure excipients, skin test, patch test, skin prick test, intradermal testAbstract
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Pajon R, Doria-Rose NA, Shen X, Schmidt SD, O'Dell S, McDanal C, et al. SARS-CoV-2 omicron variant neutralization after mRNA-1273 booster vaccination. N Engl J Med 2022; 386: 1088-1091.
https://doi.org/10.1056/NEJMc2119912 DOI: https://doi.org/10.1056/NEJMc2119912
Greenhawt M, Abrams EM, Shaker M, Chu DK, Khan D, Akin C, et al. The risk of allergic reaction to SARS-CoV-2 vaccines and recommended evaluation and management: a systematic review, meta-analysis, GRADE assessment, and international consensus approach. J Allergy Clin Immunol Pract 2021; 9: 3546-3567.
https://doi.org/10.1016/j.jaip.2021.06.006 DOI: https://doi.org/10.1016/j.jaip.2021.06.006
Català A, Muñoz-Santos C, Galván-Casas C, Roncero Riesco M, Revilla Nebreda D, Solá-Truyols A, et al. Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases. Br J Dermatol 2022; 186: 142-152.
https://doi.org/10.1111/bjd.20639 DOI: https://doi.org/10.1111/bjd.20639
Sokolowska M, Eiwegger T, Ollert M, Torres MJ, Barber D, Del Giacco S, et al. EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy 2021; 76: 1629-1639.
https://doi.org/10.1111/all.14739 DOI: https://doi.org/10.1111/all.14739
Caballero ML, Quirce S. Excipients as potential agents of anaphylaxis in vaccines: analyzing the formulations of currently authorized COVID-19 vaccines. J Investig Allergol Clin Immunol 2021; 31: 92-93.
https://doi.org/10.18176/jiaci.0667 DOI: https://doi.org/10.18176/jiaci.0667
Stingeni L, Bianchi L, Tramontana M, Pigatto PD, Patruno C, Corazza M, et al. Skin tests in the diagnosis of adverse drug reactions. G Ital Dermatol Venereol 2020; 155: 602-621.
https://doi.org/10.23736/S0392-0488.20.06698-5 DOI: https://doi.org/10.23736/S0392-0488.20.06698-5
Barbaud A, Gonçalo M, Bruynzeel D, Bircher A; European Society of Contact Dermatitis. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis 2001; 45: 321-328.
https://doi.org/10.1034/j.1600-0536.2001.450601.x DOI: https://doi.org/10.1034/j.1600-0536.2001.450601.x
Bianchi L, Biondi F, Hansel K, Murgia N, Tramontana M, Stingeni L. Skin tests in urticaria/angioedema and flushing to Pfizer-BioNTech SARS-CoV-2 vaccine: Limits of intradermal testing. Allergy 2021; 76: 2605-2607.
https://doi.org/10.1111/all.14839 DOI: https://doi.org/10.1111/all.14839
Mortz CG, Kjaer HF, Rasmussen TH, Rasmussen TH, Garvey LH, Bindslev-Jensen C. Allergy to polyethylene glycol and polysorbates in a patient cohort: diagnostic work-up and decision points for vaccination during the COVID-19 pandemic. Clin Transl Allergy 2022; 12: e12111.
https://doi.org/10.1002/clt2.12111 DOI: https://doi.org/10.1002/clt2.12111
Wolfson AR, Robinson LB, Li L, McMahon AE, Cogan AS, Fu X, et al. First-dose mRNA COVID-19 vaccine allergic reactions: limited role for excipient skin testing. J Allergy Clin Immunol Pract 2021; 9: 3308-3320.
https://doi.org/10.1016/j.jaip.2021.06.010 DOI: https://doi.org/10.1016/j.jaip.2021.06.010
Greenhawt M, Shaker M, Golden DBK. PEG/polysorbate skin testing has no utility in the assessment of suspected allergic reactions to SARS-CoV-2 vaccines. J Allergy Clin Immunol Pract 2021; 9: 3321-3322.
https://doi.org/10.1016/j.jaip.2021.06.025 DOI: https://doi.org/10.1016/j.jaip.2021.06.025
Ieven T, Van Weyenbergh T, Vandebotermet M, Devolder D, Breynaert C, Schrijvers R. Tolerability of polysorbate 80 containing COVID-19 vaccines in confirmed PEG allergic patients. J Allergy Clin Immunol Pract 2021; 9: 4470-4472.e1.
https://doi.org/10.1016/j.jaip.2021.09.039 DOI: https://doi.org/10.1016/j.jaip.2021.09.039
Wenande E, Garvey LH. Immediate-type hypersensitivity to polyethylene glycols: a review. Clin Exp Allergy 2016; 46: 907-922.
https://doi.org/10.1111/cea.12760 DOI: https://doi.org/10.1111/cea.12760
Gambichler T, Boms S, Susok L, Dickel H, Finis C, Rached NA, et al. Cutaneous findings following COVID-19 vaccination: review of world literature and own experience. J Eur Acad Dermatol Venereol 2022; 36: 172-180.
https://doi.org/10.1111/jdv.17744 DOI: https://doi.org/10.1111/jdv.17744
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Copyright (c) 2022 Leonardo Bianchi, Filippo Biondi, Katharina Hansel, Nicola Murgia, Alessandro D'Arpino, Marta Tramontana, Luca Stingeni
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