Inhibition of Transforming Growth Factor Beta and Immune Checkpoints Induces a Distinctively Distributed, Severe Bullous Pemphigoid

Authors

  • Soo Hyun Choi
  • Kyung Bae Chung
  • Do-Young Kim Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 03722 Seoul, Korea https://orcid.org/0000-0002-0194-9854

DOI:

https://doi.org/10.2340/00015555-3853

Keywords:

bullous pemphigoid, programmed cell death-1;, cancer immunotherapy, transforming growth factor

Abstract

Abstract is missing (Short communication)

Downloads

Download data is not yet available.

References

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-2454.

DOI: https://doi.org/10.1056/NEJMoa1200690

Coleman E, Ko C, Dai F, Tomayko MM, Kluger H, Leventhal JS. Inflammatory eruptions associated with immune checkpoint inhibitor therapy: a single-institution retrospective analysis with stratification of reactions by toxicity and implications for management. J Am Acad Dermatol 2019; 80: 990-997.

DOI: https://doi.org/10.1016/j.jaad.2018.10.062

Krenacs T, Kiszner G, Stelkovics E, Balla P, Teleki I, Nemeth I, et al. Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis. Histochem Cell Biol 2012; 138: 653-667.

DOI: https://doi.org/10.1007/s00418-012-0981-9

Teicher BA. TGF?-directed therapeutics: 2020. Pharmacol Ther 2021; 217: 107666.

DOI: https://doi.org/10.1016/j.pharmthera.2020.107666

Gatti-Mays ME, Gulley JL. M7824: a promising new strategy to combat cancer immune evasion. Oncoscience 2018; 5: 269-270.

DOI: https://doi.org/10.18632/oncoscience.451

Wijayanti A, Zhao CY, Boettiger D, Chiang YZ, Ishii N, Hashimoto T, et al. The reliability, validity and responsiveness of two disease scores (BPDAI and ABSIS) for bullous pemphigoid: which one to use? Acta Derm Venereol 2017; 97: 24-31.

DOI: https://doi.org/10.2340/00015555-2473

McCarron MJ, Marie JC. TGF-? prevents T follicular helper cell accumulation and B cell autoreactivity. J Clin Invest 2014; 124: 4375-4386.

DOI: https://doi.org/10.1172/JCI76179

Antiga E, Quaglino P, Volpi W, Pierini I, Del Bianco E, Bianchi B, et al. Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid. J Eur Acad Dermatol Venereol 2014; 28: 222-230.

DOI: https://doi.org/10.1111/jdv.12091

Sader F, Denis JF, Laref H, Roy S. Epithelial to mesenchymal transition is mediated by both TGF-? canonical and non-canonical signaling during axolotl limb regeneration. Sci Rep 2019; 9: 1144.

DOI: https://doi.org/10.1038/s41598-018-38171-5

Downloads

Additional Files

Published

2021-06-30

How to Cite

Choi, S. H., Chung, K. B., & Kim, D.-Y. (2021). Inhibition of Transforming Growth Factor Beta and Immune Checkpoints Induces a Distinctively Distributed, Severe Bullous Pemphigoid. Acta Dermato-Venereologica, 101(6), adv00489. https://doi.org/10.2340/00015555-3853

Issue

Vol. 101 No. 6 (2021): June

Section

Short Communication

Categories

License

Copyright (c) 2021 Soo Hyun Choi, Kyung Bae Chung, Do-Young Kim

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

Crossref
Scopus
Google Scholar
Europe PMC