Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review

Authors

  • Eveline Bijlard
  • Sanne Steltenpool
  • Frank B. Niessen

DOI:

https://doi.org/10.2340/00015555-2106

Keywords:

keloid, pathologic scar, 5-fluorouracil, treatment, corticosteroid

Abstract

In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms "keloid" and "5-FU", together with all synonyms of these terms. Two reviewers selected original research reports using 5-FU alone or combined with a maximum of 2 other therapies. Eighteen papers were found that reported either on intralesional 5-FU alone, or on 5-FU combined with triamcinolone acetonide (TAC:5-FU) or excision, including 482 patients. 5-FU treatment was effective in 45-96% of patients, but only TAC:5-FU may perform better than TAC alone. Due to a poor level of evidence, further research should establish the superiority of repeated intralesional TAC:5-FU injections over TAC alone with several doses and injection schedules.

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Published

2015-04-15

How to Cite

Bijlard, E., Steltenpool, S., & Niessen, F. B. (2015). Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review. Acta Dermato-Venereologica, 95(7), 778–782. https://doi.org/10.2340/00015555-2106

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Section

Articles