Effects of SCH23390 Injection into the Dorsal Striatum and Nucleus Accumbens on Methamphetamine-induced Gnawing and Hyperlocomotion in Rats

Noriaki KOSHIKAWA; Eiichi MORI; Koichi OKA; Hiroshi NOMURA; Noriyoshi YATSUSHIGE; Yoshiko MARUYAMA

doi:10.2334/josnusd1959.31.451

Noriaki KOSHIKAWA, Eiichi MORI, Koichi OKA, Hiroshi NOMURA, Noriyoshi YATSUSHIGE, Yoshiko MARUYAMA

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Keywords: SCH23390, methamphetamine, apomorphine, stereotyped gnawing, hyperlocomotion, dorsal striatum, nucleus accumbens

JOURNAL FREE ACCESS

1989 Volume 31 Issue 2 Pages 451-457

DOI https://doi.org/10.2334/josnusd1959.31.451

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Abstract

The effects of SCH23390, a selective D₁ receptor antagonist, injected into either the dorsal striatum or nucleus accumbens on methamphetamine-induced stereotyped gnawing and hyperlocomotion in rats were investigated. SCH23390 injected into the dorsal striatum did not alter the gnawing induced by both methamphetamine and apomorphine. However, SCH23390 injected into the nucleus accumbens significantly reduced methamphetamine-induced gnawing without altering the effects of apomorphine. Injection of SCH23390 into the nucleus accumbens reduced the hyperlocomotion produced by methamphetamine more markedly than injection of SCH23390 into the dorsal striatum.

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