Keio Uterus Transplantation Research: From Basic Research toward          Future Clinical Application

Iori Kisu; Kouji Banno; Yusuke Matoba; Yohei Yamada; Katsura Emoto; Yohei Masugi; Kentaro Matsubara; Hideaki Obara; Daisuke Aoki

doi:10.2302/kjm.2021-0008-IR

REVIEW

Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application

Iori Kisu, Kouji Banno, Yusuke Matoba, Yohei Yamada, Katsura Emoto, Yohei Masugi, Kentaro Matsubara, Hideaki Obara, Daisuke Aoki

Author information

Iori Kisu
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Kouji Banno
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Yusuke Matoba
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Yohei Yamada
Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, Japan
Katsura Emoto
Department of Pathology, Keio University School of Medicine, Tokyo, Japan
Yohei Masugi
Department of Pathology, Keio University School of Medicine, Tokyo, Japan
Kentaro Matsubara
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Hideaki Obara
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Daisuke Aoki
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan

Keywords: cynomolgus macaque, non-human primate, uterine factor infertility, uterus transplantation, surrogacy

JOURNAL FREE ACCESS FULL-TEXT HTML

2022 Volume 71 Issue 2 Pages 33-43

DOI https://doi.org/10.2302/kjm.2021-0008-IR

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Abstract

Uterus transplantation (UTx) is now a potential option to allow women with uterine factor infertility to give birth. However, UTx is still at an experimental stage, and basic animal studies, including in non-human primates, are needed for the accumulation of data prior to clinical application. Considering that UTx may provide new hope to Japanese women, we launched UTx research in 2009 and have since accumulated a large archive of results in the UTx research field. Furthermore, we have carried out various activities aimed at the implementation of clinical applications of UTx in Japan while clarifying the ethical and social issues involved. Currently, the clinical application of UTx in Japan is just around the corner, and it is expected that UTx research will develop further in the future. Herein, we summarize our basic experiences using non-human primates and our activities with the goal of future clinical applications.

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