doiSerbia

Pathogenesis of malignant ascites in ovarian cancer patients

Stanojević Zorica (Clinic of Oncology, Clinical Center Niš, Niš)
Rancić Gorana Ž. (Institute of Histology, Medical Faculty Niš, Niš)
Radić Stojan S. (Clinic of Oncology, Clinical Center Niš, Niš)
Potić-Zečević Nataša (Clinic of Oncology, Clinical Center Niš, Niš)
Đorđević Biljana (Institute of Pathology, Medical Faculty, Niš)
Marković Milan (Clinic of Oncology, Clinical Center Niš, Niš)
Todorovska Ilinka (Clinic of Oncology, Clinical Center Niš, Niš)

Peritonitis carcinomatosa, indicating the presence of malignant cells in the peritoneal cavity, is a well- known complication of malignant disease. The collection of intraperitoneal fluid in a patient with ovarian cancer is most likely due to intraperitoneal spread of disease. The recognition of small quantities of intraperitoneal fluid may have staging and prognostic significance, while symptomatic large collections may reflect end-stage disease, which permits only palliative therapeutic options. In this paper we dis- cussed the pathogenesis of malignant ascites in ovarian cancer patients and suggested potential new treatment approaches.

Keywords: ascites, ovarian neoplasms, neovascularisation, pathologic, endothelial growth factors, capillary permeability