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Synthesis, characterization and antimicrobial activity of isothiocyanato Fe(III) Girard's t hydrazone complex

Čobeljić Božidar (Faculty of Chemistry, Belgrade)
Pevec Andrej (University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, Slovenia)
Jagličić Zvonko (University of Ljubljana, Institute of Mathematics, Physics and Mechanics & Faculty of Civil and Geodetic Engineering, Ljubljana, Slovenia)
Milenković Milica R. (Faculty of Chemistry, Belgrade)
Turel Iztok (University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, Slovenia)
Radanović Dušanka (Institute of Chemistry, Technology and Metallurgy, Belgrade)
Milenković Marina (Faculty of Pharmacy, Department of Microbiology and Immunology, Belgrade)
Anđelković Katarina (Faculty of Chemistry, Belgrade)

The isothiocyanato Fe(III) complex with (E)-N,N,N-trimethyl-2-oxo- -2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium was synthesized and characterized by elemental analysis, IR spectroscopy and X-ray analysis. The octahedral geometry of the Fe(III) complex consists of the deprotonated form of the hydrazone ligand coordinated through the pyridine nitrogen, azomethine nitrogen and carbonyl oxygen atoms with three isothiocyanato ligands in the remaining coordination places. The measured effective magnetic moment for Fe(III) complex corresponds to high spin Fe(III) ion. The hydrazone ligand and its Fe(III) complex showed lower activity against the tested microbial strains than standard antimicrobial drugs.

Keywords: hydrazone, X-ray structure, magnetic properties, pseudohalides