doiSerbia

Antibacterial and antioxidant activities of Licania tomentosa (Benth.) fritsch (crhysobalanaceae)

Silva J.B.N.F. (Universidade Federal de Pernambuco - UFPE; Departamento de Antibióticos - DANT; Laboratório de Bioensaios para Pesquisa de Fármacos - LBPF, Recife (PE), Brazil)
Menezes I.R.A. (Laboratório de Farmacologia e Química Molecular- LFQM, Crato (CE), Brazil)
Coutinho H.D.M. (Laboratório de Microbiologia e Biologia Molecular- LPPN, Crato (CE), Brazil)
Rodrigues F.F.G. (Universidade Regional do Cariri - URCA; Departamento de Química Biológica - DQB; Laboratório de Pesquisa em Produtos Naturais - LPPN, Crato (CE), Brazil + Faculdade Leão Sampaio, Juazeiro do Norte, (CE), Brazil)
Costa J.G.M. (Universidade Regional do Cariri - URCA; Departamento de Química Biológica - DQB; Laboratório de Pesquisa em Produtos Naturais - LPPN, Crato (CE), Brazil + Faculdade Leão Sampaio, Juazeiro do Norte, (CE), Brazil)
Felipe C.F.B. (Faculdade Leão Sampaio, Juazeiro do Norte, (CE), Brazil)

This work describes the chemical composition, and evaluates the antimicrobial and antioxidant activities of a hydroalcoholic extract from the leaves of the Licania tomentosa. Gram positive and negative bacterial strains were used in this work. Examination of the phytochemical composition of L. tomentosa revealed the presence of secondary metabolites such as tannins, flavonoids, saponins, alkaloids, steroids and triterpenoids. An antibacterial assay pointed out that the extract had a lower minimal inhibitory concentration (MIC - 32 μg/mL) towards Staphylococcus aureus (ATCC12692). The extract also presented antibacterial activity against other assayed bacteria, with the MIC varying between 64 and 512 μg/ mL. Our findings reveal that the extract presented an antioxidative capacity lower than that of BHT at the same concentration, used as positive control. Our results suggest that the levels and combinations between the secondary metabolites of this plant should be investigated to explain the demonstrated antibacterial activity.

Keywords: Licania tomentosa, Chrysobalanaceae, antibacterial activity, antioxidant activity