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Research Article

Co-delivery of chlorin e6 and doxorubicin using PEGylated hollow nanocapsules for ‘all-in-one’ tumor theranostics

    Qian Li

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    ,
    Mengmeng Hou

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    ,
    Junjie Ren

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    ,
    Shiyu Lu

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    ,
    Zhigang Xu

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    ,
    Chang Ming Li

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    ,
    Yuejun Kang

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    &
    Peng Xue

    *Author for correspondence:

    E-mail Address: xuepeng@swu.edu.cn

    Key Laboratory of Luminescent & Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials & Energy, Southwest University, Chongqing 400715, PR China

    Chongqing Engineering Research Center for Micro-Nano Biomedical Materials & Devices, Southwest University, Chongqing 400715, PR China

    Published Online:https://doi.org/10.2217/nnm-2019-0099

    Aim: Hollow mesoporous copper sulfide nanocapsules conjugated with poly(ethylene glycol) (PEG), doxorubicin and chlorin e6 (HPDC) were synthesized for fluorescence imaging and multimodal tumor therapy. Materials & methods: HPDC were synthesized by encapsulating chlorin e6 and doxorubicin into PEGylated nanocapsules via a simple precipitation method. The photothermal/photodynamic effects, drug release, cellular uptake, imaging capacities and antitumor effects of the HPDCs were evaluated. Results: This smart nanoplatform is stimulus-responsive toward an acidic microenvironment and near infrared laser irradiation. Moreover, fluorescence imaging-guided and combined photothermal/photodynamic/chemotherapies of tumors were promoted under laser activation and led to efficient tumor ablation, as evidenced by exploring animal models in vivo. Conclusion: HPDCs are expected to serve as potent and reliable nanoagents for achieving superior therapeutic outcomes in cancer management.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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