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Blinatumomab-induced donor T-cell activation for post-stem cell transplant-relapsed acute CD19-positive biphenotypic leukemia

    Mohammed Alcharakh

    Research Assistant, Hematology Department of Medicine, University of Arizona, AZ, USA

    Authors contributed equally as co-first authors.

    Search for more papers by this author

    ,
    Seongseok Yun

    Department of Medicine, University of Arizona, AZ, USA

    Authors contributed equally as co-first authors.

    Search for more papers by this author

    ,
    Yimin Dong

    Department of Pathology, University of Arizona, AZ, USA

    ,
    Nicole D Vincelette

    Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, MN, USA

    ,
    Madiha Daud

    Research Assistant, Hematology Department of Medicine, University of Arizona, AZ, USA

    ,
    Saima Manzoor

    Research Assistant, Hematology Department of Medicine, University of Arizona, AZ, USA

    ,
    Irbaz Bin Riaz

    Research Assistant, Hematology Department of Medicine, University of Arizona, AZ, USA

    &
    Faiz Anwer

    *Author for correspondence:

    E-mail Address: anwerf@email.arizona.edu

    Department of Medicine, University of Arizona, AZ, USA

    Division of Hematology, Oncology, Blood & Marrow Transplantation, University of Arizona, Tucson, AZ 86721, USA

    Published Online:https://doi.org/10.2217/imt-2015-0023

    Post-stem cell transplantation (SCT) relapsed acute lymphoblastic leukemia (ALL) has extremely poor prognosis with median survival of less than 1 year. Donor lymphocyte infusion, second transplantation, chemotherapy or cytokine treatment have been tried as a salvage regimen without significant clinical benefit. Recently, blinatumomab, a bispecific monoclonal antibody targeting CD3-expressing T cells and CD19-expressing B-cell lineage malignant cells demonstrated promising outcomes in relapsed/refractory ALL patients. Literature on blinatumomab use in biphenotypic ALL along with Philadelphia chromosome positive (Ph+) ALL is limited. We report a case of post-SCT relapsed CD19 expressing biphenotypic lymphoblastic leukemia patient who achieved complete remission after blinatumomab treatment and has lasting remission for 1 year.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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