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Diagnostic Evaluation

Accelerate Pheno™ blood culture detection system: a literature review

    Elio Cenci‡

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    Microbiology, Perugia General Hospital, Perugia, Italy

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Riccardo Paggi‡

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Giuseppe V De Socio

    Clinic of Infectious Diseases, Perugia General Hospital, Perugia, Italy

    ,
    Silvia Bozza

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    Microbiology, Perugia General Hospital, Perugia, Italy

    ,
    Barbara Camilloni

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    Microbiology, Perugia General Hospital, Perugia, Italy

    ,
    Donatella Pietrella

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    Microbiology, Perugia General Hospital, Perugia, Italy

    &
    Antonella Mencacci

    *Author for correspondence: Tel.: +39 075 578 4277;

    E-mail Address: antonella.mencacci@unipg.it

    Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy

    Microbiology, Perugia General Hospital, Perugia, Italy

    Published Online:https://doi.org/10.2217/fmb-2020-0177

    Accelerate Pheno™ (ACC) is a fully automated system providing rapid identification of a panel of bacteria and yeasts, and antimicrobial susceptibility testing of common bacterial pathogens responsible for bloodstream infections and sepsis. Diagnostic accuracy for identification ranges from 87.9 to 100%, and antimicrobial susceptibility testing categorical agreement is higher than 91%. The present review includes peer-reviewed studies on ACC published to date. Both interventional and hypothetical studies evidenced the potential positive clinical role of ACC in the management and therapy of patients with bloodstream infections and sepsis, due to the important reduction in time to report, suggesting a crucial impact on the therapeutic management of these patients, provided the presence of a hospital antimicrobial stewardship program, a 24/7 laboratory operating time and a strict collaboration between clinical microbiologist and clinician. Further prospective multicenter studies are necessary to explore the impact of this system on mortality, length of stay and spread of multidrug-resistant organisms.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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