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Research Article

Relation between LRG1 and CD4+ T cells, cognitive impairment and neurological function in patients with acute ischemic stroke

    Xiao Cheng

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

    Shanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, 030009, China

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    ,
    Hongen Wei

    *Author for correspondence: Tel.: +86 0351 496 0171;

    E-mail Address: shine0xiao1988@163.com

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

    Shanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, 030009, China

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    ,
    Yi Liu

    **Author for correspondence: Tel.: +86 0351 496 0171;

    E-mail Address: yiji918268@163.com

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

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    ,
    Yaxuan Sun

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

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    ,
    Jianxin Ye

    Department of Neurology, The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Fuzhou, 350000, China

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    ,
    Pengyu Lu

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

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    &
    Bin Han

    Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China

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    Published Online:21 Feb 2024https://doi.org/10.2217/bmm-2023-0674

    Abstract

    Objective: To assess the relationship between LRG1 and CD4+ T cells, cognitive impairment and neurological function in acute ischemic stroke (AIS). Methods: Plasma LRG1 was detected by ELISA in 175 patients with AIS at baseline, day (D) 1, D7, month (M) 1 and M3. Results: LRG1 was negatively related to Th2 and Treg cells and positively linked to Th17 (all p < 0.05). LRG1 increased from baseline to D1, then decreased until M3 (p < 0.001). LRG1 at each assessment point was increased in patients with cognitive impairment or poor neurological function at M3 versus those without (all p < 0.05). Conclusion: LRG1 is linked to decreased Th2 and Tregs, increased Th17, cognitive impairment and nonideal neurological function recovery in patients with AIS.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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