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Short Communication

Endothelial biomarkers in the light of new sepsis definition

    Dunja Mihajlovic

    *Author for correspondence: Tel.: +38 164 033 3820;

    E-mail Address: dunja.mihajlovic@mf.uns.ac.rs

    Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Emergency Center, Novi Sad, Serbia

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    ,
    Snezana Brkic

    Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia

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    ,
    Dajana Lendak

    Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia

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    ,
    Aleksandra Novakov Mikic

    Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

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    ,
    Biljana Draskovic

    Faculty of Medicine, University of Novi Sad, Institute of Child & Adolescent Health Care of Vojvodina, Clinic of Pediatric Surgery, Novi Sad, Serbia

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    &
    Gorana Mitic

    Faculty of Medicine, Department of Hematology, Hemostasis, & Prevention of Thrombosis, University of Novi Sad, Clinical Center of Vojvodina, Laboratory Medicine Center,  Novi Sad, Serbia

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    Published Online:28 Mar 2019https://doi.org/10.2217/bmm-2018-0282

    Abstract

    The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model. Conclusion: Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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