We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Investigating the application of FDM 3D printing pattern in preparation of patient-tailored dosage forms

    Pavan Kumar Nukala

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Siddhant Palekar

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Nayan Solanki

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Yige Fu

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Manali Patki

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Ali A Shohatee

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    ,
    Louis Trombetta

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    &
    Ketan Patel

    *Author for correspondence:

    E-mail Address: patelk2@stjohns.edu

    Department of Pharmaceutical Sciences, St. Albert's Hall, 8000 Utopia Parkway, Queens, NY 11439, USA

    Published Online:https://doi.org/10.2217/3dp-2018-0028

    Aim: The aim of this work was to investigate the effect of printing pattern on physical attributes and dissolution of fused deposition modeling 3D printed caplets. Methods: Hydrochlorothiazide-loaded polyvinyl alcohol filaments were prepared by hot melt extrusion. Caplets printed in hexagonal (HexCap), diamond infill (DiaCap) in three different sizes using fused deposition modeling 3D printer and evaluated for hardness, disintegration and dissolution. Results: DiaCaps exhibited higher hardness than HexCaps. Disintegration time for HexCaps was <20 mins. while DiaCaps took 25–40 mins. DiaCaps showed 20–30% lower release at all time points compared with HexCaps. Conclusion: Although composition, processing parameters were same, mere change in printing pattern alters disintegration and dissolution. Findings of this study can be invaluable in developing patient-tailored medicines.

    References

    • 1 US FDA. Paving the way for personalized medicine (2013). https://www.fdanews.com/ext/resources/files/10/10-28-13-Personalized-Medicine.pdf (last accessed on January 11th 2018).
    • 2 Alhnan MA, Okwuosa TC, Sadia M, Wan KW, Ahmed W, Arafat B. Emergence of 3D printed dosage forms: opportunities and challenges. Pharm. Res. 33(8), 1817–1832 (2016).
    • 3 Skowyra J, Pietrzak K, Alhnan MA. Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur. J. Pharm. Sci. 68, 11–17 (2015).
    • 4 Tagami T, Nagata N, Hayashi N et al. Defined drug release from 3D-printed composite tablets consisting of drug-loaded polyvinylalcohol and a water-soluble or water-insoluble polymer filler. Int. J. Pharm. 543(1–2), 361–367 (2018).
    • 5 Davoodi P, Lee LY, Xu Q et al. Drug delivery systems for programmed and on-demand release. Adv. Drug Deliv. Rev. 132, 104–138 (2018).
    • 6 Goyanes A, Wang J, Buanz A et al. 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Mol. Pharm. 12(11), 4077–4084 (2015).
    • 7 Lim SH, Kathuria H, Tan JJY, Kang L. 3D printed drug delivery and testing systems – a passing fad or the future? Adv. Drug Deliv. Rev. 132, 139–168 (2018).
    • 8 Lopez FL, Ernest TB, Tuleu C, Gul MO. Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert Opin. Drug Deliv. 12(11), 1727–1740 (2015).
    • 9 Pardeike J, Strohmeier DM, Schrodl N et al. Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. Int. J. Pharm. 420(1), 93–100 (2011).
    • 10 Raijada D, Genina N, Fors D et al. A step toward development of printable dosage forms for poorly soluble drugs. J. Pharm. Sci. 102(10), 3694–3704 (2013).
    • 11 Sadee W. Personalized therapeutics and pharmacogenomics: integral to personalized health care. Pharm. Res. 34(8), 1535–1538 (2017).
    • 12 Wening K, Breitkreutz J. Oral drug delivery in personalized medicine: unmet needs and novel approaches. Int. J. Pharm. 404(1–2), 1–9 (2011).
    • 13 Ricles LM, Coburn JC, Di Prima M, Oh SS. Regulating 3D-printed medical products. Sci. Transl. Med. 10(461), eaan6521 (2018).
    • 14 Awad A, Trenfield SJ, Gaisford S, Basit AW. 3D printed medicines: a new branch of digital healthcare. Int. J. Pharm. 548, 586–596 (2018).
    • 15 Jamróz W, Szafraniec J, Kurek M, Jachowicz R. 3D printing in pharmaceutical and medical applications – recent achievements and challenges. Pharm. Res. 35(9), 176 (2018).
    • 16 Awad A, Trenfield SJ, Goyanes A, Gaisford S, Basit AW. Reshaping drug development using 3D printing. Drug Discov. Today 23, 1547–1555 (2018).
    • 17 Goyanes A, Robles Martinez P, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. Int. J. Pharm. 494(2), 657–663 (2015).
    • 18 Jamroz W, Kurek M, Lyszczarz E et al. 3D printed orodispersible films with aripiprazole. Int. J. Pharm. 533(2), 413–420 (2017).
    • 19 Trenfield SJ, Awad A, Goyanes A, Gaisford S, Basit AW. 3D printing pharmaceuticals: drug development to frontline care. Trends Pharmacol. Sci. 39(5), 440–451 (2018).
    • 20 Alhijjaj M, Belton P, Qi S. An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. Eur. J. Pharm. Biopharm. 108, 111–125 (2016).
    • 21 Goole J, Amighi K. 3D printing in pharmaceutics: a new tool for designing customized drug delivery systems. Int. J. Pharm. 499(1–2), 376–394 (2016).
    • 22 Norman J, Madurawe RD, Moore CM, Khan MA, Khairuzzaman A. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv. Drug Deliv. Rev. 108, 39–50 (2017).
    • 23 Okwuosa TC, Stefaniak D, Arafat B, Isreb A, Wan KW, Alhnan MA. A lower temperature FDM 3D printing for the manufacture of patient-specific immediate release tablets. Pharm. Res. 33(11), 2704–2712 (2016).
    • 24 Sadia M, Sosnicka A, Arafat B et al. Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets. Int. J. Pharm. 513(1–2), 659–668 (2016).
    • 25 Ghosh U, Ning S, Wang Y, Kong YL. Addressing unmet clinical needs with 3D printing technologies. Adv. Healthcare Mater. 7(17), 1800417 (2018).
    • 26 Fuenmayor E, Forde M, Healy AV et al. Material considerations for fused-filament fabrication of solid dosage forms. Pharmaceutics 10(2), 44 (2018).
    • 27 Sadia M, Arafat B, Ahmed W, Forbes RT, Alhnan MA. Channelled tablets: an innovative approach to accelerating drug release from 3D printed tablets. J. Control. Rel. 269, 355–363 (2018).
    • 28 Solanki NG, Tahsin M, Shah AV, Serajuddin ATM. Formulation of 3D printed tablet for rapid drug release by fused deposition modeling: screening polymers for drug release, drug-polymer miscibility and printability. J. Pharm. Sci. 107(1), 390–401 (2018).
    • 29 Jonathan G, Karim A. 3D printing in pharmaceutics: a new tool for designing customized drug delivery systems. Int. J. Pharm. 499(1–2), 376–394 (2016).
    • 30 Zhang J, Feng X, Patil H, Tiwari RV, Repka MA. Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int. J. Pharm. 519(1–2), 186–197 (2017).
    • 31 Sun Y, Rui Y, Wenliang Z, Tang X. Nimodipine semi-solid capsules containing solid dispersion for improving dissolution. Int. J. Pharm. 359(1–2), 144–149 (2008).
    • 32 Goyanes A, Buanz AB, Hatton GB, Gaisford S, Basit AW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur. J. Pharm. Biopharm. 89, 157–162 (2015).
    • 33 Khaled SA, Burley JC, Alexander MR, Roberts CJ. Desktop 3D printing of controlled release pharmaceutical bilayer tablets. Int. J. Pharm. 461(1–2), 105–111 (2014).
    • 34 Pietrzak K, Isreb A, Alhnan MA. A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur. J. Pharm. Biopharm. 96, 380–387 (2015).
    • 35 Solanki NG, Tahsin M, Shah AV, Serajuddin ATM. Formulation of 3D printed tablet for rapid drug release by fused deposition modeling: screening polymers for drug release, drug-polymer miscibility and printability. J. Pharma. Sci. 107(1), 390–401 (2018).
    • 36 Konta A, García-Piña M, Serrano D. Personalised 3D printed medicines: which techniques and polymers are more successful? Bioengineering 4(4), 79 (2017).
    • 37 Goyanes A, Fernández-Ferreiro A, Majeed A et al. PET/CT imaging of 3D printed devices in the gastrointestinal tract of rodents. Int. J. Pharm. 536(1), 158–164 (2018).
    • 38 Choonara YE, Du Toit LC, Kumar P, Kondiah PP, Pillay V. 3D-printing and the effect on medical costs: a new era? Expert Rev. Pharmacoeconomics Outcomes Res. 16(1), 23–32 (2016).
    • 39 Sanphui P, Rajput L. Tuning solubility and stability of hydrochlorothiazide co-crystals. Acta Crystallogr. B 70(1), 81–90 (2014).
    • 40 Palekar S, Nukala PK, Mishra SM, Kipping T, Patel K. Application of 3D printing technology and quality by design approach for development of age-appropriate pediatric formulation of baclofen. Int. J. Pharm. 556, 106–116 (2018).
    • 41 Patki M, Patel K. Development of a solid supersaturated self-nanoemulsifying preconcentrate (S-superSNEP) of fenofibrate using dimethylacetamide and a novel co-processed excipient. Drug Dev. Ind. Pharm. 1–10 (2018).
    • 42 Gupta P, Kakumanu VK, Bansal AK. Stability and solubility of celecoxib-PVP amorphous dispersions: a molecular perspective. Pharm. Res. 21(10), 1762–1769 (2004).
    • 43 Liu F, Ranmal S, Batchelor HK et al. Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations. Drugs 74(16), 1871–1889 (2014).
    • 44 Goyanes A, Scarpa M, Kamlow M, Gaisford S, Basit AW, Orlu M. Patient acceptability of 3D printed medicines. Int. J. Pharm. 530(1–2), 71–78 (2017).
    • 45 Gupta SS, Solanki N, Serajuddin AT. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, IV: affinisol HPMC HME polymers. AAPS PharmSciTech 17(1), 148–157 (2016).
    • 46 Zheng M, Bauer F, Birk G, Lubda D. Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs (2017). https://www.europeanpharmaceuticalreview.com/wp-content/uploads/PVA-in-HME-to-Improve-Solubility_Poster_A3_EN_MSIG_Mar2017_low.pdf (last accessed on January 11th 2018).
    • 47 De Jaeghere W, De Beer T, Van Bocxlaer J, Remon JP, Vervaet C. Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications. Int. J. Pharm. 492(1–2), 1–9 (2015).
    • 49 Melocchi A, Parietti F, Maroni A, Foppoli A, Gazzaniga A, Zema LJIJOP. Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling. 509(1–2), 255–263 (2016).
    • 50 Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol. Pharm. 67(3), 217–223 (2010).
    • 51 Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 13(2), 123–133 (2001).
    • 52 Saurí J, Millán D, Suñé-Negre J et al. Quality by design approach to understand the physicochemical phenomena involved in controlled release of captopril SR matrix tablets. Int. J. Pharm. 477(1–2), 431–441 (2014).
    • 53 Lee PI. Kinetics of drug release from hydrogel matrices. J. Control. Rel. 2, 277–288 (1985).
    • 54 Long J, Gholizadeh H, Lu J, Bunt C, Seyfoddin A. Application of fused deposition modelling (FDM) method of 3D printing in drug delivery. Curr. Pharm. Des. 23(3), 433–439 (2017).
    • 55 Goyanes A, Kobayashi M, Martínez-Pacheco R, Gaisford S, Basit AW. Fused-filament 3D printing of drug products: microstructure analysis and drug release characteristics of PVA-based caplets. Int. J. Pharm. 514(1), 290–295 (2016).
    • 56 Khaled SA, Alexander MR, Irvine DJ et al. Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech 19(8), 3403–3416 (2018).
    • 57 Gioumouxouzis CI, Katsamenis OL, Bouropoulos N, Fatouros DG. 3D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug delivery. J. Drug Deliv. Sci. Technol. 40, 164–171 (2017).
    • 58 Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J. Control. Release 217, 308–314 (2015).