Vitamin D level and indicators of carbohydrate metabolism in women with polycystic ovary syndrome

Authors

  • T.L. Arkhypkina V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine, Kharkiv, Ukraine
  • V.A. Bondarenko V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine, Kharkiv, Ukraine
  • O.A. Goncharova Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • L.P. Lyubimovа V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine, Kharkiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0721.16.5.2020.212740

Keywords:

polycystic ovary syndrome, vitamin D, insulin resistance, sex steroid-binding globulin

Abstract

Background. Polycystic ovary syndrome (PCOS) remains an urgent problem of gynecological endocrinology, and its frequency is approximately 11–17 % among women of reproductive age and reaches 75 % in the structure of endocrine infertility. There is evidence that vitamin D impacts carbohydrate metabolism, and its insufficiency or deficiency increases the risk of impaired glucose tolerance, insulin resistance and type 2 diabetes mellitus (DM). The purpose of this study is to determine the relationship between vitamin D levels and indicators of carbohydrate metabolism in wo­men with polycystic ovary syndrome. Materials and methods. Sixty women aged from 19 to 26 years were examined: 30 women with a diagnosis of the classical phenotype of PCOS; 30 healthy women with normal menstrual and reproductive function. We stu­died the content of vitamin D, sex steroid-binding globulin (SSBG), immunoreactive insulin (IRI), HOMA-IR index, body mass index (BMI), waist-hip ratio. Depending on the concentration of vitamin D, women were divided into subgroups: the first enrolled 22 patients with PCOS with vitamin D ≤ 30 ng/ml (average level 12.9 ± 0.2 ng/ml); the second included 8 patients with a level of vitamin D ≥ 30 ng/ml (31.4 ± 0.3 ng/ml); the third group consisted of 12 healthy women with vitamin D ≤ 30 ng/ml (24.2 ± 0.3 ng/ml); fourth group consisted of 18 healthy women with a level of vitamin D ≥ 30 ng/ml (35.6 ± 0.3 ng/ml). Results. It was found that in the basic group of PCOS patients, the average level of vitamin D (21.4 ± 0.4 ng/ml) was significantly lower (P < 0.001) compared to the group of healthy women (29.6 ± 0.3 ng/ml). In patients with PCOS, low concentrations of vitamin D were accompanied by hig­her levels of glucose (P < 0.001), IRI (P < 0.001), HOMA-IR index (P < 0.001), and a decreased level of SSBG (P < 0.001). A negative association of vitamin D with BMI (r = –0.399; P < 0.05), waist-hip ratio (r = –0.612; P < 0.001), IRI concentration (r = –0.502; P < 0.001), HOMA-IR index (r = –0.571; P < 0.001), the level of SSBG (r = –0.694; P < 0.001) was established. Conclusions. The results of the study demonstrate the role of abdominal obesity in the formation of vitamin D deficiency, which intensifies the carbohydrate metabolism disorders, increases hyperinsulinemia, insulin resistance and reduces the production of sex steroid-binding globulin in women with PCOS.

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Published

2020-09-27

How to Cite

Arkhypkina, T., Bondarenko, V., Goncharova, O., & Lyubimovа L. (2020). Vitamin D level and indicators of carbohydrate metabolism in women with polycystic ovary syndrome. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 16(5), 381–386. https://doi.org/10.22141/2224-0721.16.5.2020.212740

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Original Researches

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