Authors

Department of pediatric Endocrinology and Metabolism, Mashhad university of medical science, Mashhad, Iran.

Abstract

McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities.
 We describe a girl patient with MAS having precocious puberty and multiple cafe-au-lait macules and deforming polyostotic fibrous dysplasia of bone.
Clinical presentation and X-ray finding were strongly diagnostic for MAS, Patients with McCune-Albright syndrome reach the adult age with a significant burden of the disease that continuously reduces their quality of life. Skeletal deformities, fractures, hyperthyroidism, and hyperestrogenism are just few of the many challenges in the management of these patients. These disorders with close observation and early detection can be controlled.

Keywords

Introduction

 McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a sporadic, somatic, post-zygotic mutation characterized by a triad of polyostotic fibrous dysplasia (FD), café-au-lait maculae and hyperfunctional endocrine glands. [1,2] The disorder is more common in females [3] , It is a rare disease with an estimated prevalence between 1/100,000 and 1/1,000,000. [4]  The café-au-lait skin pigmentation consist of large hypermelanostic maculae of irregular and serpinginous (coast of maine) borders, which occur mainly on the front , posterior area of the neck, buttocks, thorax, back ,shoulder and pelvis. [5,6]

 FD is a benign condition in which the medullary portion of the bone is replaced by poorly organized fibrous tissue with trabeculae of immature bone.[7] It may affect either a single bone (monostotic) or numerous bones (polyostotic). [1] It is caused by embryonic somatic mutation leading to substitution of (His) or (Cys) for (Arg) at amino acid 201 of the Alpha-Subunit of the signal transduction protein Gs (Gs Alpha). [2] Recent studies have shown a clonal origin for FD, suggesting that this lesion is neoplastic in nature. [8] The endocrine disorders associated with this disease may include precocious puberty, hyperthyroidism, pituitary adenomas, adrenal primary hyperplasia, hypophosphatemia, and ovarian cysts. [6]

Precocious puberty is the common clinical presentation and girls are affected more than boys. [1,5] The non-classical form consists of only two of these three conditions.

 Gonadotropin-independent precocious puberty is the most common endocrine involvement described. A number of other endocrine and non-endocrine organs may be involved, including the adrenal, thyroid, pituitary, liver and heart. Here we report a case of MAS with this triad of symptoms.

        Case presentation

 The discussed patient first has been referred to department of pediatric endocrinology and metabolism Mashhad’s university of medical sciences with a complaint of Breast enlargement, at the age of 6.

At the time of admission the patient weighed 25 kg (W-Z score = 1.21) with a height of 128cm (H-Z score = 2.35), Therefore having a BMI of 15.3 kg/m².

On physical examination, she had enlarged breasts (Tanner stage 2–3) with pigmentation of the areola(figure 1)

 Figure 1 Breast enlargment in 6 years old girl with precocious puberty

 A pelvic ultrasound revealed a left ovarian cysts measuring 3.70´3.4 cm. The uterus was enlarged with a length of 4.6 cm (normal ≤ 3 cm) and had a prominent endometrium.

The patient’s bone age in radiographic evaluation, was measured 8 according to Greuliche and Pyle atlas of skeletal maturation [9]

Hormonal analysis revealed an elevated level of estradiol 113pg/mL (normal < 36 pg/mL) and LH 1.7 mlu/ml (normal < 1mlu/ml); D.H.E.A SO4 and FSH were all in their normal range.

The patient was diagnosed with central precocious puberty, and therefore went under treatment with GnRH agonists.

    At third month follow-up, the patient complained of pain in lower limb area and Radiographic evaluations revealed a series of fibrodysplastic changes (figure 2)

            Figure 2 fibrodysplastic changes of femur in 6 years old girl present with precocious puberty

 After re evaluation, She was diagnosed with McCune-Albright syndrome According to precocious puberty, bone changes and café-au-lait maculae observed. (figure3)

 Figure 3 café-au-lait maculs in the right side of her face who presented with precocious puberty

  In addition to re evaluation of endocrine glands and other organs no abnormal finding was detected, and the patient was prescribed with intravenous Pamidronate at a dose of 1-2mg/kg/day for 3 days every 3 months.

In her last visit at the age of 7.5, she weighed 33 kgs, with a height of 127cm, and her BMI was 20.4 kg/m².puberty development was under control and lower limb pain had remitted significantly.  

   Discussion

 MAS is a rare multisystem disorder, first described in 1937 separately by Donovan McCune and Fuller Albright in a group of children, mostly females, with skin pigmentation, bone deformities and endocrinal disorders that develops from an activating mutation in the Gs gene [2,10].

The disorder is the result of post-zygotic somatic mutation in the gene GNAS 1 on chromosome 20q13-13.2 9, [11]coding for the alpha subunit of stimulatory G protein (Gsa).G proteins couple cell surface receptors to intracellular proteins to activate or inactivate signaling cascades. The stimulatory G protein is normally activated when a hormone or other ligand binds to the cell surface receptor. The activated Gsa subunit subsequently dissociates from the receptor, binds to adenylyl cyclase and stimulates an increase in the intracellular cyclic adenosine monophosphate (cAMP) levels. The Gsa subunit is then inactivated, which re-associates with the receptor and is again available for hormone-mediated reactivation.

The clinical expression depends on the number of mutated cells and affected organs. Thus, the presentation can be heterogenous, involving various endocrine and non-endocrine organs.

It can be early or late onset or slow or quick evolution. This abnormality lead to proliferation of osteoprogenitor cells without differentiation, therefore fibrous matrix with woven bone increase. MAS is diagnosed on the triad of  FD, endocrinopathy and hyperpigmentation of the skin. [12]

The clinical presentation of MAS is highly variable, depending on which of the various potential components of the syndrome predominate. The classical form of MAS is more common in females and is defined by a triad of physical signs as described above.

Café-au-lait macules (CALMs) develop between the age of 4 months and 2 years, but may be present at birth.

Bone dysplasia is revealed during the first decade by aching pain, pathological fractures, limb asymmetry and deformities. Abnormal fibrous tissue growth occurs in many bones, especially in the long bones, ribs and skull bones. Fibrous dysplasia ranges from small asymptomatic areas, detectable only by bone scan, to markedly disfiguring lesions, resulting in pathological fractures and impingement on vital structures. Radiographic appearance can be pagetoid (56%), sclerotic (23%) or cystic (21%).[13] Although once considered a rare finding, fibrous dysplasia of the vertebrae leading to scoliosis is found in 40% of the patients with polyostotic fibrous dysplasia in a study by Leet et al. [14]

No definite treatment is available for MAS and, to date, prenatal diagnosis is not possible. But, recently, through novel polymerase chain reaction-based techniques, activating mutation in the peripheral blood of patients with MAS has been successfully detected, which might help in diagnostic as well therapeutic areas.[11,15]

Various medical and surgical treatments are offered for endocrine and non-endocrine involvement according to signs and symptoms.

Corrective surgery can be performed for bone dysplasia. Recently, bisphosphonate therapy has shown promise for fibrous dysplasia patients as it helps to diminish pain, prevents fracture and leads to partial resolution of fibrous dysplasia lesions. [16]

 Conclusion

 The precocious puberty can also be an early manifestation of McCune-Albright syndrome and the etiologic diagnosis of early sexual precocity is based on careful history and physical examination.

Children with precocious puberty should be evaluated for endocrinopathies and hormonal studies may be necessary in such cases.

  

 

1. Nielsen GP, Layfield LJ, Rosenberg AE. Neoplastic and tumor  like lesions of bone. IN: Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, WickMR, eds. Silverberg principles and practice of surgical pathology and cytopathology Vol. 1.4th ed. Philadelphia: Churchil Livingstone Elsevier,2006:740-742
 
2. Zhou J, Sun LH, Cui B, Song HD, Li XY, Ning G, Liu JM. Genetic diagnosis of
multiple affected tissues in a patient with McCune-Albright syndrome. Endocrine. 2007 Apr; 31(2):212-7. PubMed PMID: 17873334.
3. Albright F, Butler AM, Hampton AO. Syndrome characterized by osteitisfibrosadisseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females. N Engl J Med 1937;216:727-47
4. Dumitrescu CE, Collins MT. McCune-Albright syndrome. Orphanet J Rare Dis. 2008May 19; 3:12. doi: 10.1186/1750-1172-3-12. PubMed PMID: 18489744; PubMed Central PMCID: PMC2459161.
5.RosenbergAE.bones,joint and soft tissue tumors In: Kumar V,abbasAK,Fausto N, eds. Robins and Cotran pathologic basis of disease. 7th ed. Philadelphia: Elsevier Saundes; 2005:1300-1301
6. Xavier SP, Ribeiro MC, Sicchieri LG, Brentegani LG, Lacerda SA. Clinical,
microscopic and imaging findings associated to McCune-Albright syndrome: report of two cases. Braz Dent J. 2008;19(2):165-70. PubMed PMID: 18568233.
7. Medow JE, Agrawal BM, Resnick DK. Polyostotic fibrous dysplasia of the cervical spine: case report and review of the literature. Spine J. 2007
Nov-Dec;7(6):712-5. Epub 2007 Feb 2. Review. PubMed PMID: 17434805.
8. Mikami M, Koizumi H, Ishii M, Nakajima H. The identification of monoclonality in fibrous dysplasia by methylation-specific polymerase chain reaction for the human androgen receptor gene. Virchows Arch. 2004 Jan; 444(1):56-60. Epub 2003 Oct 24. PubMed PMID: 14576938.
9. Greuliche WW, Pyle SI.Radiographic  atlas of skeletal development of the hand and wriste. 2th ed.1959. Standford University Press.
 
10. Liang LY, Meng Z, Zeng QH, Li WY. McCune-Albright syndrome: a difficult and complicated case study. Zhongguo Dang Dai ErKeZaZhi. 2006 Aug; 8(4):311-4. Chinese. PubMed PMID: 16923365.
11. DiCaprio MR, Enneking WF. Fibrous dysplasia. Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am 2005; 87:1848-64.
 
12.Papadopoulou M, Doula S, Kitsios K, Kaltsas T, Kosta K. A boy with
McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment. Hormones (Athens). 2006Jul-Sep;5(3):205-9. PubMed PMID: 16950755.
 
13. Singer FR. Fibrous dysplasia of bone: the bone lesion unmasked. Am J Pathol 1997;151:1511-5.  
14. Leet AI, Magur E, Lee JS, Wientroub S, Robey PG, Collins MT. Fibrous dysplasia in the spine: Prevalence of lesions and associations with scoliosis. J Bone Joint Surg Am 2004; 86:531-7.   
15. Lietman SA, Ding C, Levine MA. A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia. J Bone Joint Surg Am 2005; 87:2489-94.  
16. Lane JM, Khan SN, O'Connor WJ, Nydick M, Hommen JP, Schneider R, et al. Bisphosphonate therapy in fibrous dysplasia. ClinOrthopRelat Res 2001; 382:6-12.