Haemodynamic induced acute renal failure in equine colic - a light and electronmicroscopical investigation in healthy and diseased kidneys

Licht- und elektronenmikroskopische Darstellung des proximalen Tubulus bei gesunden Pferden und kolikkranken Pferden mit hämodynamisch induziertem akuten Nierenversagen

Schulze S W, Budras K-D, Schusser G F

DOI: 10.21836/PEM20040201
Year: 2004
Volume: 20
Issue: 2
Pages: 118-126

The proximal tubule is the primary site of reabsorption of water and electrolytes specially sodium. Hemodynamically acute renal failure is mediated by severe intravascular volume deficit and/or endotoxemia due to horses with strangulation obstruction. Destruction of the epithelium of the proximal tubule decreases one of the major function of the kidney. The damages of the epithelium of the proximal tubule were demonstrated by collecting kidneys of 9 horses. Six horses had strangulation obstruction, three were normal. An exact representation of the fine structures of the individual sections of the nephron could be obtained on the basis of the light and electron microscopy. Distention of the proximal tubuli, increased numbers of endocytotic apical vacuoles, increase of size, loss of the brush border of the epithelial cells of the proximal tubuli, areas of disseminated intravascular thrombi and interstitiell edema were seen light microscopically. Apical blebs and luminal casts are found significantly by scanning electron microscopy. Cell necrosis and isolated epithelial cells in tubular lumen were detected by transmission electron microscopic study. In all colic horses the GGT/Creatine ratio was markedly increased and correlated with the morphological changes in the proximal tubule. Encymuria and morphological changes of the proximal tubule are signs of acute renal failure in these colic horses which has been mediated hemodynamically by marked hemoconcentration.