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Drug Delivery Letters

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ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

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Research Article

Mucoadhesive Buccal Patch Role in Emesis: Tweaked up by the Pivotal Permeation Enhancer: Sodium Lauryl Sulphate

Author(s): Kumar Nishchaya*, Swatantra K.S. Kushwaha, Namra Aziz, Himanshu Bansode, Jagriti Tiwari and Abhitendra Kumar

Volume 10, Issue 2, 2020

Page: [96 - 103] Pages: 8

DOI: 10.2174/2210303109666191010161007

Price: $65

Abstract

Background: It has been observed that several diseases either acute or chronic have a specific symptom that is emesis. Emesis leads to depletion and removal of several salts and biological essentials required in the body. Domperidone is a D2 receptor antagonist, which triggers the chemoreceptor trigger zone (CTZ) and hence used in the management of nausea and vomiting.

Objective: The objective of this project was to formulate a buccal patch of domperidone with the use of several polymers with a permeation enhancer. Since the oral bioavailability of domperidone is low due to gastric degradation, hence a buccal patch was prepared to determine its bioavailability. The purpose of this study was to formulate a buccal patch for better bioavailability and observe the effect of permeation enhancer with polymers.

Methods: The mucoadhesive buccal patch was prepared using the solvent cast method. The characterization studies were done along with the drug content and compatibility studies through FTIR.

Results: It was observed that the polymers; sodium carboxy methyl cellulose (SCMC) & polyvinyl alcohol(PVA) without sodium lauryl sulphate (SLS) had low drug release, which was around 68% and 72%, respectively whereas polymers with SLS had markedly increased drug release, which was around 89% and 91%, respectively.

Conclusion: In order to obtain the maximum therapeutic efficacy of domperidone, buccal patches are considered much more beneficial than oral dosage form. Permeation enhancer also helps to synergize the effect of polymers which helps in better drug release and ultimately leads to better bioavailability.

Keywords: Domperidone, buccal patch, permeation enhancer, sodium lauryl sulphate, sodium carboxy methyl cellulose, polyvinyl alcohol.

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Graphical Abstract

[1]
Information about drugs used in palliative care available at: www.palliativedrugs.com (Accessed on March 7, 2005).
[2]
Palem, C.R.; Gannu, R.; Doodipala, N.; Yamsani, V.V.; Yamsani, M.R. Transmucosal delivery of domperidone from bilayered buccal patches: in vitro, ex vivo and in vivo characterization. Arch. Pharm. Res., 2011, 34(10), 1701-1710.
[http://dx.doi.org/10.1007/s12272-011-1014-2] [PMID: 22076770]
[3]
Carvalho, F.C.; Bruschi, M.L.; Evangelista, R.C.; Gremiao, M.P.D. Mucoadhesive drug delivery systems. Braz. J. Pharm. Sci., 2010, 46, 1-17.
[http://dx.doi.org/10.1590/S1984-82502010000100002]
[4]
Shahid, K.; Mayank, V.; Geeta, A.; Hari, K.S.L. Mucoadhesive drug delivery system : a review. World J. Pharm. Pharm. Sci., 2016, 5, 392-405.
[http://dx.doi.org/10.20959/wjpps20174-8863]
[5]
Patel, K.R.; Patel, M.R.; Mehta, T.J.; Patel, A.D.; Patel, N.M. Formulation, Development and Evaluation of Mucoadhesive Buccal Patch of Carvedilol. Int. J. Pharmagenesis., 2011, 2, 31-41.
[6]
Khan, S.; Parvez, N.; Sharma, P.K.; Alam, A.M.; Warsi, M.H. Novel aproaches - mucoadhesive buccal drug delivery system. Int. J. Res. Dev. Pharm. Life Sci., 2016, 5, 2201-2208.
[7]
Neelagiri, R. Reddy, M.S.; Rao, N.G.R. Buccal Patch As Drug Delivery System : an Overview. Int. J. Curr. Pharm. Res., 2013, 5, 40-47.
[8]
Dodla, S.; Velmurugan, S. Buccal penetration enhancers-An overview. Asian. J. Pharm. Clin. Res., 2013, 6, 39-47.
[9]
Alexander, A. Ajazuddin; Swarna; Sharma, M.; Tripathi, D.K. Polymers and Permeation Enhancers : Specialized Components of Mucoadhesives. S. J. Pharm. Sci., 2011, 4, 91-95.
[http://dx.doi.org/10.3329/sjps.v4i1.8878]
[10]
Meher, J.G.; Yadav, N.P.; Yadav, K.S.; Rai, V. Buccal Drug Delivery System and Penetration Enhancer : A Review. Pharm. Rev., 2012, 113-117.
[11]
Razzak, S.M.I.; Khan, F.; Hossain, M.; Anika, T.; Moon, S.A. Impact of Sodium Lauryl Sulphate on the release of Carbamazepine from Methocel K15M CR based matrix tablets. Bangla. Pharm. J., 2012, 15, 79-82.
[12]
Lodhi, M.; Dubey, A.; Narayan, R.; Prabhu, P.; Priya, S. Formulation and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris. Int. J. Pharm. Investig., 2013, 3(1), 47-53.
[http://dx.doi.org/10.4103/2230-973X.108963] [PMID: 23799205]
[13]
Castán, H.; Ruiz, M.A.; Clares, B.; Morales, M.E. Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia. Drug Deliv., 2015, 22(6), 869-876.
[http://dx.doi.org/10.3109/10717544.2014.896958] [PMID: 24670096]
[14]
Khairnar, A.; Jain, P.; Baviskar, D.; Jain, D. Development of mucoadhesive buccal patch containing acelofenac in vitro evaluations. Int. J. Pharm. Tech. Res., 2009, 1(14), 978-981.
[http://dx.doi.org/10.1007/s12272-011-1014-2] [PMID: 22076770]
[15]
Panigrahi, L.; Pattnaik, S.; Ghosal, S.K. Design and characterization of mucoadhesive buccal patches of salbutamol sulphate. Acta Pol. Pharm., 2004, 61(5), 351-360.
[PMID: 15747691]
[16]
Kumar, M.; Garg, G.; Kumar, P.; Kulkarni, G.T.; Kumar, A. Design and invitro evaluation of mucoadhesive buccal film containing Famotidine. Int. J. Pharm. Pharm. Sci., 2010, 2, 86-90.
[17]
Verma, N.; Chattopadhyay, P. Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia. J. Adv. Pharm. Technol. Res., 2014, 5(2), 96-103.
[http://dx.doi.org/10.4103/2231-4040.133436] [PMID: 24959419]
[18]
Rao, N.G.R.; Shravani, B.; Reddy, M.S. Overview on buccal drug delivery systems. J. Pharm. Sci. Res., 2013, 5, 80-88.
[19]
Augusthy, A.R.; Vipin, K.V.; Chandran, S.C.; Thushara, M.V.; Shahin, M.T.K. Formulation and Evaluation of Mucoadhesive Buccal Film of Lisinopril. Res. Rev: J. Pharma. Nano., 2013, 2, 45-51.

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