Abstract
Cardiac fibrosis occurs in response to numerous factors including ischemia, myocardial scarring after infarction, pressure overload of the heart, and a complex interplay of multiple hormonal systems. Transforming growth factor-beta (TGF-β) is a locally generated cytokine that participates in healing processes and tissue fibrosis following cardiac injury. TGF-β1 induces the proliferation of cardiac fibroblasts and their phenotypic transformation to myofibroblasts, and the deposition of extracellular matrix (ECM). This review examines current knowledge on TGF-β signal transduction pathways and the effects of TGF-β inhibition on the development of cardiac fibrosis. Improved understanding of the actions and signaling of this cytokine system may lead to the development of new therapeutic strategies that combat the development of myocardial fibrosis in the pathogenesis of heart failure.
Keywords: Transforming growth factor-beta, inhibition, cardiac fibrosis
Current Enzyme Inhibition
Title: The Role of Transforming Growth Factor-β in Cardiac Fibrosis
Volume: 6 Issue: 2
Author(s): Leigh J. Ellmers
Affiliation:
Keywords: Transforming growth factor-beta, inhibition, cardiac fibrosis
Abstract: Cardiac fibrosis occurs in response to numerous factors including ischemia, myocardial scarring after infarction, pressure overload of the heart, and a complex interplay of multiple hormonal systems. Transforming growth factor-beta (TGF-β) is a locally generated cytokine that participates in healing processes and tissue fibrosis following cardiac injury. TGF-β1 induces the proliferation of cardiac fibroblasts and their phenotypic transformation to myofibroblasts, and the deposition of extracellular matrix (ECM). This review examines current knowledge on TGF-β signal transduction pathways and the effects of TGF-β inhibition on the development of cardiac fibrosis. Improved understanding of the actions and signaling of this cytokine system may lead to the development of new therapeutic strategies that combat the development of myocardial fibrosis in the pathogenesis of heart failure.
Export Options
About this article
Cite this article as:
J. Ellmers Leigh, The Role of Transforming Growth Factor-β in Cardiac Fibrosis, Current Enzyme Inhibition 2010; 6 (2) . https://dx.doi.org/10.2174/157340810791233024
DOI https://dx.doi.org/10.2174/157340810791233024 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Use of Diverse Chemometric and Validation Methods to Accurately Predict Human Urotensin-II Receptor Antagonist Activity
Current Computer-Aided Drug Design Diabetic Cardiomyopathy and Oxidative Stress: Role of Antioxidants
Cardiovascular & Hematological Agents in Medicinal Chemistry Antihypertensive Properties of Angiotensin-Converting Enzyme Inhibitors (ACEI) Independent of the Renin-Angiotensin System
Current Hypertension Reviews Recent Developments on Endothelin Antagonists as Immunomodulatory Drugs - from Infection to Transplantation Medicine
Recent Patents on Cardiovascular Drug Discovery PPAR-Gamma in Ulcerative Colitis: A Novel Target for Intervention
Current Drug Targets Vitamin D in Acute Kidney Injury
Inflammation & Allergy - Drug Targets (Discontinued) Applications of Michael Addition Reaction in Organic Synthesis
Current Organic Synthesis The Application of Angiotensin Converting Enzyme Inhibitors in Heart Surgery
Letters in Drug Design & Discovery Pregnane X Receptor and its Potential Role in Drug Resistance in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery MiR-147: Functions and Implications in Inflammation and Diseases
MicroRNA HTLV-1 Associated Neurological Disorders
Current Topics in Medicinal Chemistry Phosphatidylinositol 3-Kinase Isoforms as Novel Drug Targets
Current Drug Targets Emerging Therapy Options in Heparin-Induced Thrombocytopenia
Cardiovascular & Hematological Agents in Medicinal Chemistry Nitric Oxide Synthase and Cyclooxygenase Pathways: A Complex Interplay in Cellular Signaling
Current Medicinal Chemistry New Insights into Redox-Modulated Cell Signaling
Current Pharmaceutical Design Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling
Current Drug Targets Pharmacogenomic Considerations of the Insertion / Deletion Gene Polymorphism of the Angiotensin I-Converting Enzyme and Coronary Artery Disease
Current Vascular Pharmacology Management of Acute Coronary Syndromes in Patients with Renal Insufficiency
Current Cardiology Reviews Editorial (Hot Topic: Introduction to the Special Issue: Relevance of Endocrine and Metabolic Disorders in Heart Failure: From Pathophysiology to Therapeutic Approach)
Endocrine, Metabolic & Immune Disorders - Drug Targets Anticancer Agents Derived from Natural Products
Mini-Reviews in Medicinal Chemistry