Abstract
The prevalence of obesity and its associated disorders [e.g., insulin resistance, type 2 diabetes and cardiovascular disease (CVD)] has seen a rapid increase in recent years. As such, understanding the mechanisms underlying dietinduced insulin resistance has been a topic of interest. In line with this notion, postprandial oxidative stress has received considerable attention over the past several years due to its involvement in the etiology of the above mentioned conditions. In fact, postprandial oxidative stress has been suggested to be the unifying mechanism in the connection between insulin resistance, Type 2 diabetes and CVD. In addition to this growing association, recent data are now available suggesting a causal role for such prooxidant stress in the development of insulin resistance. This review is intended to provide an overview of literature pertaining to the role of free radical production following feeding, as related to the development of insulin resistance, Type 2 diabetes and CVD.
Keywords: Postprandial, Free radicals, Oxidative stress, Insulin resistance, Hyperglycemia, Hypertriglyceridemia
Current Diabetes Reviews
Title: Macronutrient Specific Postprandial Oxidative Stress: Relevance to the Development of Insulin Resistance
Volume: 5 Issue: 4
Author(s): Kelsey Fisher-Wellman and Richard J. Bloomer
Affiliation:
Keywords: Postprandial, Free radicals, Oxidative stress, Insulin resistance, Hyperglycemia, Hypertriglyceridemia
Abstract: The prevalence of obesity and its associated disorders [e.g., insulin resistance, type 2 diabetes and cardiovascular disease (CVD)] has seen a rapid increase in recent years. As such, understanding the mechanisms underlying dietinduced insulin resistance has been a topic of interest. In line with this notion, postprandial oxidative stress has received considerable attention over the past several years due to its involvement in the etiology of the above mentioned conditions. In fact, postprandial oxidative stress has been suggested to be the unifying mechanism in the connection between insulin resistance, Type 2 diabetes and CVD. In addition to this growing association, recent data are now available suggesting a causal role for such prooxidant stress in the development of insulin resistance. This review is intended to provide an overview of literature pertaining to the role of free radical production following feeding, as related to the development of insulin resistance, Type 2 diabetes and CVD.
Export Options
About this article
Cite this article as:
Fisher-Wellman Kelsey and Bloomer J. Richard, Macronutrient Specific Postprandial Oxidative Stress: Relevance to the Development of Insulin Resistance, Current Diabetes Reviews 2009; 5 (4) . https://dx.doi.org/10.2174/157339909789804369
DOI https://dx.doi.org/10.2174/157339909789804369 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tyrosine Kinase Inhibitor-Induced Hypertension: Role of Hypertension as a Biomarker in Cancer Treatment
Current Vascular Pharmacology Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies
Current Medicinal Chemistry Antivitamin K Drugs in Stroke Prevention
Current Vascular Pharmacology T Cell Response in Rheumatic Fever: Crossreactivity Between Streptococcal M Protein Peptides and Heart Tissue Proteins
Current Protein & Peptide Science A More Accurate Approach to Molecular Genetics Analysis in Vascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Anabolic-androgenic Steroid use and Psychopathology in Athletes. A Systematic Review
Current Neuropharmacology Glucans as Biological Response Modifiers
Endocrine, Metabolic & Immune Disorders - Drug Targets High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease
Current Pharmaceutical Design The Promise of Cholesteryl Ester Transfer Protein (CETP) Inhibition in the Treatment of Cardiovascular Disease
Current Pharmaceutical Design Editorial (Thematic Issue: Current Therapeutic Options in Cardiomyopathies)
Current Pharmaceutical Design Health Benefits of Honey: Implications for Treating Cardiovascular Diseases
Current Nutrition & Food Science Multiplexed Fluorescence Imaging of Tumor Biomarkers in Gene Expression and Protein Levels for Personalized and Predictive Medicine
Current Molecular Medicine Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets
Current Topics in Medicinal Chemistry Statins as Either Immunomodulators or Anti-Cancer Drugs: Functional Activities on Tumor Stromal Cells and Natural Killer Cells
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Effects of Different Types of Physical Exercise on the Perceived Quality of Life in Active Elderly
CNS & Neurological Disorders - Drug Targets Detection of Ventricular Arrhythmias using HRV Analysis and Quadratic Features
Recent Advances in Electrical & Electronic Engineering Role of Gut Microbiota in Human Health and Diseases
Current Nutrition & Food Science Knowledge and Perceptions Towards Cardiovascular Disease Prevention Among Patients with Type 2 Diabetes Mellitus: A Review of Current Assessments and Recommendations
Current Diabetes Reviews SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-Related Vascular Diseases
Current Molecular Medicine Molecular Imaging of Vascular Inflammation
Current Pharmaceutical Design