Abstract
Obstructive sleep apnea syndrome (OSAS) is a common sleep-related breathing disorder that affects up to 7-10% of men and 4-5% of women. It is characterized by repeated events of complete or partial upper airway occlusion occurring during sleep, accompanied by a gradually increasing effort to breathe and terminated by an arousal when the upper airway patency is restored. The most effective treatment option for OSAS is continuous positive airway pressure (CPAP) therapy. There are numerous studies that had linked, without any scientific doubt, OSAS with cardiovascular diseases, morbidity and mortality. In the recent years it became evident as well that acute cerebrovascular events, such as stroke, are also a consequence of obstructive sleep apnea, although the pathophysiology and the mechanisms are not clear as of yet. This mini-review attempts to clarify and to highlight clinically important issues concerning sleep apnea and stroke patients with the aim of their optimal, effective and safe management.
Keywords: Obstructive sleep apnea, stroke, cerebrovascular morbidity, cerebrovascular mortality, continuous positive airway pressure.
Current Respiratory Medicine Reviews
Title:Stroke as a Consequence of Sleep Apnea: Epidemiology, Pathophysiology and Treatment Strategies
Volume: 11 Issue: 4
Author(s): Silvia V. Dumitru and Epameinondas N. Kosmas
Affiliation:
Keywords: Obstructive sleep apnea, stroke, cerebrovascular morbidity, cerebrovascular mortality, continuous positive airway pressure.
Abstract: Obstructive sleep apnea syndrome (OSAS) is a common sleep-related breathing disorder that affects up to 7-10% of men and 4-5% of women. It is characterized by repeated events of complete or partial upper airway occlusion occurring during sleep, accompanied by a gradually increasing effort to breathe and terminated by an arousal when the upper airway patency is restored. The most effective treatment option for OSAS is continuous positive airway pressure (CPAP) therapy. There are numerous studies that had linked, without any scientific doubt, OSAS with cardiovascular diseases, morbidity and mortality. In the recent years it became evident as well that acute cerebrovascular events, such as stroke, are also a consequence of obstructive sleep apnea, although the pathophysiology and the mechanisms are not clear as of yet. This mini-review attempts to clarify and to highlight clinically important issues concerning sleep apnea and stroke patients with the aim of their optimal, effective and safe management.
Export Options
About this article
Cite this article as:
V. Dumitru Silvia and N. Kosmas Epameinondas, Stroke as a Consequence of Sleep Apnea: Epidemiology, Pathophysiology and Treatment Strategies, Current Respiratory Medicine Reviews 2015; 11 (4) . https://dx.doi.org/10.2174/1573398X11666150915213142
DOI https://dx.doi.org/10.2174/1573398X11666150915213142 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Impact of Fenofibrate on Type 2 Diabetes Patients with Features of the Metabolic Syndrome: Subgroup Analysis From FIELD
Current Cardiology Reviews Mesenchymal Stem Cells: New Approaches for the Treatment of Neurological Diseases
Current Stem Cell Research & Therapy Apolipoprotein E Knockout Models
Current Pharmaceutical Design Evaluation of Blood Pressure Control using a New Arterial Stiffness Parameter, Cardio-ankle Vascular Index (CAVI)
Current Hypertension Reviews Recent Patents on Implantable Drug/Protein Delivery Systems Fabricated Using Electrospinning
Recent Patents on Biomedical Engineering (Discontinued) Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore Modeling, Docking Studies, In vitro Screening, and 3D-QSAR Analysis
Current Computer-Aided Drug Design When Cells Become a Drug. Endothelial Progenitor Cells for Cardiovascular Therapy: Aims and Reality
Recent Patents on Cardiovascular Drug Discovery Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer's Disease in Chinese Population
Current Alzheimer Research Sleep Apnea and Coronary Heart Disease: From Dusk Till Dawn and Further
Current Respiratory Medicine Reviews The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease
Current Medicinal Chemistry Small Molecule Antagonists of the Chemokine Receptor CCR5
Current Topics in Medicinal Chemistry Roles of miRNA in Cardiovascular Development and Dysfunction
Current Medicinal Chemistry Dual-acting of Hybrid Compounds - A New Dawn in the Discovery of Multi-target Drugs: Lead Generation Approaches
Current Topics in Medicinal Chemistry Systematic Review of Public Education and Policy for Stroke Prevention
Current Drug Targets Ultrasound Features of Polycystic Ovaries and Syndrome X: A Pilot Study
Vascular Disease Prevention (Discontinued) Hypothyroidism and Endothelial Function: A Marker of Early Atherosclerosis?
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery A Collaborative Edge-Cloud Internet of Things Based Framework for Securing the Indian Healthcare System
International Journal of Sensors, Wireless Communications and Control Pharmacology of the Human Saphenous Vein
Current Vascular Pharmacology Insights Into the Role of microRNAs in Cardiac Diseases: From Biological Signalling to Therapeutic Targets
Cardiovascular & Hematological Agents in Medicinal Chemistry Endothelial Dysfunction in Cardiac Allograft Vasculopathy: Potential Pharmacological Interventions
Current Vascular Pharmacology