Abstract
Papillary carcinoma of the thyroid is a common malignancy originating from the endocrine organs. The recent prevalence of ultrasonography (US) and US-guided fine needle aspiration biopsy (FNAB) can make us easily diagnose papillary carcinoma of 1.0 cm or less in maximal diameter, which is called papillary microcarcinoma. How to treat papillary microcarcinoma has been controversial. In autopsy studies, papillary carcinoma of 3-9.9 mm is frequently found as an occult carcinoma. Furthermore, papillary carcinoma of more than 3 mm was detected in 3.5% of otherwise healthy women aged 30 years or older by mass screening using US and FNAB, and 84% of them were less than 1.5 cm in diameter. These findings indicate that papillary microcarcinoma frequently remains occult. Thus, recently, a trial of observation without surgical treatment has been performed, which demonstrates that most papillary microcarcinoma do not grow or only slowly grow and observation can be a therapeutic strategy. On the other hand, previous reports demonstrated that papillary microcarcinoma frequently metastasizes to cervical lymph nodes and shows multiple tumor formation in the thyroid. Furthermore, cases with palpable nodal metastasis often show rapid progression and dire prognosis. In this review, we discuss the appropriate application of observation and surgical treatment of papillary microcarcinoma.
Keywords: thyroid cancer, microcarcinoma, surgery, observation
Current Cancer Therapy Reviews
Title: Therapeutic Strategies for Papillary Microcarcinoma of the Thyroid
Volume: 1 Issue: 1
Author(s): Yasuhiro Ito and Akira Miyauchi
Affiliation:
Keywords: thyroid cancer, microcarcinoma, surgery, observation
Abstract: Papillary carcinoma of the thyroid is a common malignancy originating from the endocrine organs. The recent prevalence of ultrasonography (US) and US-guided fine needle aspiration biopsy (FNAB) can make us easily diagnose papillary carcinoma of 1.0 cm or less in maximal diameter, which is called papillary microcarcinoma. How to treat papillary microcarcinoma has been controversial. In autopsy studies, papillary carcinoma of 3-9.9 mm is frequently found as an occult carcinoma. Furthermore, papillary carcinoma of more than 3 mm was detected in 3.5% of otherwise healthy women aged 30 years or older by mass screening using US and FNAB, and 84% of them were less than 1.5 cm in diameter. These findings indicate that papillary microcarcinoma frequently remains occult. Thus, recently, a trial of observation without surgical treatment has been performed, which demonstrates that most papillary microcarcinoma do not grow or only slowly grow and observation can be a therapeutic strategy. On the other hand, previous reports demonstrated that papillary microcarcinoma frequently metastasizes to cervical lymph nodes and shows multiple tumor formation in the thyroid. Furthermore, cases with palpable nodal metastasis often show rapid progression and dire prognosis. In this review, we discuss the appropriate application of observation and surgical treatment of papillary microcarcinoma.
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Cite this article as:
Ito Yasuhiro and Miyauchi Akira, Therapeutic Strategies for Papillary Microcarcinoma of the Thyroid, Current Cancer Therapy Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573394052952546
DOI https://dx.doi.org/10.2174/1573394052952546 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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