Abstract
A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.
Keywords: Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.
Current Organic Synthesis
Title:Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones
Volume: 10 Issue: 3
Author(s): Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen and Liang-Xian Liu
Affiliation:
Keywords: Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.
Abstract: A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.
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Cite this article as:
Qin Wen-Bing, Chang Qiong, Luo Hai-Qinq, Bao Yun-Hong, Chen Zheng-Wang and Liu Liang-Xian, Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030012
DOI https://dx.doi.org/10.2174/1570179411310030012 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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